Jack&KatiesMommy wrote:Hello:
Thank you for sharing! Can you explain what you mean about no surgery required? I applied for this trial over a year ago and was told that I needed a solid tumor to harvest in order to participate. (At that time I only had malignant lymph nodes.) Is having a 1cm tumor that is easy to harvest still a requirement for participation?
Cynthia
DH2Sleen wrote:Jack&KatiesMommy wrote:Hello:
Thank you for sharing! Can you explain what you mean about no surgery required? I applied for this trial over a year ago and was told that I needed a solid tumor to harvest in order to participate. (At that time I only had malignant lymph nodes.) Is having a 1cm tumor that is easy to harvest still a requirement for participation?
Cynthia
You are right that the normal TIL trial requires a tumor harvest. But if someone is Kras G12V with HLA:11.01, then they already have a treatment which only requires the apheresis (about 4 hour process) and the chemo-prep, cell infusion, and recovery. Since they already know the mutation and compatibility, they do not require a tumor harvest.
mhf1986 wrote:How does one get tested for the particular mutations? I've read on this board about the Foundation One testing for the Keytruda trials...is that the same thing?
DH did have some testing done but I don't know if it went this far in detail. Our original oncologist didn't seem hopeful about anything so we left him and went to Hopkins.
We are about 15 miles north of NIH...I drive by there most every day to get to my office.
Thanks, M
boxhill wrote:I'm G12D, but currently have no detectable masses.
It seems that they want people with solid tumors so that they can evaluate the effectiveness. Or am I reading it wrong?
DH2Sleen wrote:I think you are right about that. The use RECIST criteria to evaluate effectiveness, so they need four to six tumors to remain after treatment to watch them for response. But they may have other trials for people who are NED. It never hurts to call.
NHMike wrote:What would be the purpose for people who are NED? Is this to harvest cells that might be usable for treating other people?
Do they have a way to get your Alleles? Also, do they take C*8:02 along with A*11:01?
DH2Sleen wrote:NHMike wrote:What would be the purpose for people who are NED? Is this to harvest cells that might be usable for treating other people?
Do they have a way to get your Alleles? Also, do they take C*8:02 along with A*11:01?
So many questions...
I don't know all of the NIH trials, but I think they have some trials in which they are looking at preventing recurrence, so those would be for NED patients.
The only allele they admit to having ready is A*11:01. But as you note, they could easily put together an engineered TCR for sleen's mutation-HLA combination. They just are not publicizing it.
My point is answering Boxhill's question is that everyone should consider working with NIH and let the experts slot them into the trial that is right for their condition.
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