violet9583 wrote:My wife had 8 rounds of FOLFOX + ERBUTAX and 4 rounds of FOLFIRI + ERBUTAX but the recent scans showed new tumors in the peritoneum. Oncologist wants her to stop Conventional Chemo and start with clinical trials. We live in DFW area. Does any one know of promising clinical trials for BRAF mutation for colon cancer?
Steph20021 wrote:violet9583 wrote:My wife had 8 rounds of FOLFOX + ERBUTAX and 4 rounds of FOLFIRI + ERBUTAX but the recent scans showed new tumors in the peritoneum. Oncologist wants her to stop Conventional Chemo and start with clinical trials. We live in DFW area. Does any one know of promising clinical trials for BRAF mutation for colon cancer?
I’m going to be starting this phase 3 trial soon for braf v600e mutation:
NHMike wrote:You've been through a very tough time. I hope that this trial works for you.
Steph20021 wrote:The trial continues to go smoothly. The only side effects I have are drowsiness/fatigue which could be caused by my pain pump actually and receiving more medicine than I actually need as my pain has gone way down. I use only one bolus a week and before about 3 a day. The rash is still only on my face and the medicated lotion keeps the redness down and the itchy away. My cea dropped at least 3.5 with the first two cycles. It wasn’t taken right when I started but a month before which is why I say at least 3.5 down after two cycles/two weeks.
My first scan is on December 18th and I can’t wait because all signs to me point to this trial working at shrinking my cancer. I’ll keep you posted with my results.
I’m curious if like chemo this stuff (encorafenib pills and the infusion of erbitux) could potentially work until a point and the stop working? I am guessing yes since in the safety study only 10% had complete response.
I can’t wait for my scan!!! Two more weeks!
Steph20021 wrote:I am still waiting to see the report from my first CT since starting the Beacon trial but I wanted to share some news. A reminder that I’m in the arm of trial with ceruximab and encorafenib.
On November 20 my CEA was 15.9 and on December 24 (after 5 cycles) it was down to 5.1!!! I haven’t been this low since after my surgeries!
My nurse said she can’t show me the report yet but that the largest rumour has shown a small bit of shrinkage as has the one in my abdomen wall that used to cause pain, everything else is stable. No new spots and no growth.
I’ll post once I’ve seen the report myself.
Also they removed two moles that had changed and sent them to biopsy as this trial does cause skin toxicity and benign squamous cell carcinoma.