Any body knows of Clinical trials for BRAF 600?

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violet9583
Posts: 7
Joined: Tue Feb 27, 2018 12:04 pm

Any body knows of Clinical trials for BRAF 600?

Postby violet9583 » Tue Aug 21, 2018 10:50 am

My wife had 8 rounds of FOLFOX + ERBUTAX and 4 rounds of FOLFIRI + ERBUTAX but the recent scans showed new tumors in the peritoneum. Oncologist wants her to stop Conventional Chemo and start with clinical trials. We live in DFW area. Does any one know of promising clinical trials for BRAF mutation for colon cancer?

NHMike
Posts: 1788
Joined: Fri Jul 21, 2017 3:43 am

Re: Any body knows of Clinical trials for BRAF 600?

Postby NHMike » Tue Aug 21, 2018 8:57 pm

This is a list of BRAF V600E trials at Mass General Hospital in Boston. There are other BRAF 600 variant trials on that page as well. The NCT numbers are listed so you can cross-reference those with any local hospitals.

BRAF V600E is a tough mutation.

http://targetedcancercare.massgeneral.o ... (c-1799T-A).aspx
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Tue Sep 18, 2018 6:11 pm

violet9583 wrote:My wife had 8 rounds of FOLFOX + ERBUTAX and 4 rounds of FOLFIRI + ERBUTAX but the recent scans showed new tumors in the peritoneum. Oncologist wants her to stop Conventional Chemo and start with clinical trials. We live in DFW area. Does any one know of promising clinical trials for BRAF mutation for colon cancer?


I’m going to be starting this phase 3 trial soon for braf v600e mutation:

https://clinicaltrials.gov/ct2/show/NCT02928224
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox

NHMike
Posts: 1788
Joined: Fri Jul 21, 2017 3:43 am

Re: Any body knows of Clinical trials for BRAF 600?

Postby NHMike » Tue Sep 18, 2018 7:04 pm

Steph20021 wrote:
violet9583 wrote:My wife had 8 rounds of FOLFOX + ERBUTAX and 4 rounds of FOLFIRI + ERBUTAX but the recent scans showed new tumors in the peritoneum. Oncologist wants her to stop Conventional Chemo and start with clinical trials. We live in DFW area. Does any one know of promising clinical trials for BRAF mutation for colon cancer?


I’m going to be starting this phase 3 trial soon for braf v600e mutation:

https://clinicaltrials.gov/ct2/show/NCT02928224


Best wishes on the clinical trial. Please keep us informed on your progress.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Tue Sep 18, 2018 8:45 pm

Thanks Mike. I will for sure check in often and keep you all posted.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Mon Nov 05, 2018 7:08 pm

I am finally starting the Beacon trial tomorrow. I got randomized into the doublet arm so I’ll be receiving the encorafenib (oral pill) and cetuximab (infusion) but not the binimetinib in the triplet arm. Oh well. Better than the control I guess, fingers crossed. I’ll let you know how it goes.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox

NHMike
Posts: 1788
Joined: Fri Jul 21, 2017 3:43 am

Re: Any body knows of Clinical trials for BRAF 600?

Postby NHMike » Mon Nov 05, 2018 9:09 pm

You've been through a very tough time. I hope that this trial works for you.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Wed Nov 07, 2018 2:50 pm

Beacon Trial update:
Started the trial yesterday (double arm-encorafenib And Cetuximab) and finished the infusion about 430pm and started vomiting with a killer migraine at 5:30pm. No premeds were given-is this normal? Called the oncall last night and got ondansetron late last night.
It was a terrible night and the migraine has been constant.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Wed Nov 07, 2018 2:53 pm

NHMike wrote:You've been through a very tough time. I hope that this trial works for you.

Thanks Mike. I really hope it helps too. It has been quite the journey these last 4.5+ years I have to say. There was a lot of human error which resulted in a delay of starting the beacon trial but I’m glad to finally have it underway.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox

Steph20021
Posts: 540
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Any body knows of Clinical trials for BRAF 600?

Postby Steph20021 » Sat Nov 10, 2018 9:45 am

Beacon Trial Update:
Night 1- lots of vomiting all night and a blinding migraine
Day 2-still a terrible migraine
Day 3-headache and body aches but I go to work; I believe I start to get a couple red welts and pimples on my face and going down my neck a bit
Day 4- body aches worsen to extremely painful arms and legs and hips and so I keep wanting to keep moving and shaking out my legs and arms but nothing helps, pins and needles behind my knees and elbows making it so I can’t walk (diagnosed with a bladder infection and I asked for a litre of saline to help my kidneys as I felt I was dehydrated but all my electeolytes came back normal. Given an antibiotic for bladder and naproxen for body aches).
My trial nurse told me to give the encorafenib a break for a couple of days to see if it’s the cause of the pins and needles and painful extremities. So I skipped the pills in day 4 and will today on day 5 too.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E mutation
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Aug/16- on folfiri
Jan/18-folfox


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