NIH trial update .. my T cells are growing!!

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teri3
Posts: 396
Joined: Fri Jan 09, 2015 11:03 am

NIH trial update .. my T cells are growing!!

Postby teri3 » Tue Aug 07, 2018 6:55 pm

I got some exciting news today from NIH after 3 months on pins and needles...my cells are growing! They are having me come in August 16th for another check in to see how I'm doing, with a possible start of the TIL trial the end of September.
I also got more good news my lung mets have shrunk or are stable after 3 months on FOLFIRI +Avistan. A good day all around.
Teri :) :)
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

stu
Posts: 901
Joined: Sat Aug 17, 2013 5:46 pm

Re: NIH trail update .. my T cells are growing!!

Postby stu » Wed Aug 08, 2018 3:01 am

Yippee. That’s the best news ever . Hope it all goes well for you . Good news days are the best .
Take care,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

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DH2Sleen
Posts: 80
Joined: Thu Jan 29, 2015 10:10 am

Re: NIH trail update .. my T cells are growing!!

Postby DH2Sleen » Wed Aug 08, 2018 5:23 am

That is such awesome new Teri. Go cells Go. Good luck to you and kill those bad cells.
DW, Sleen dx 9/2013 @47yo: IIIc T4b N2b MX
09/2013 colectomy
10/2013 - 3/2014 FOLFOX
04/2014 - 6/2014 Rad to bladder
12/2014 +'ve for lung mets, MX becomes M1
03/2015 enter TIL trial @ NIH
07/01/15 Receive 148E9 cells to target K-ras G12D mutation
08/11/15 Reduction=18%, no new tumors
09/15/15 25%
10/20/15 27%; PET -> one hot met
11/24/15 30% all mets shrinking
01/26/16 46% but one suspicious met
03/24/16 46% but one growing
04/07/16 Lung lobectomy NED for the first time

teri3
Posts: 396
Joined: Fri Jan 09, 2015 11:03 am

Re: NIH trail update .. my T cells are growing!!

Postby teri3 » Wed Aug 08, 2018 7:52 am

Thank you Stu! I've got my fingers crossed and prayers sent
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

teri3
Posts: 396
Joined: Fri Jan 09, 2015 11:03 am

Re: NIH trail update .. my T cells are growing!!

Postby teri3 » Wed Aug 08, 2018 7:59 am

@ DH2Sleen I want to.thank you and Celine for directing me this way. When I was diagnosed stage4 you and Celine encouraged me go for trials, this was before Celine went into the TIL trial. I listened and found and
amazing oncologist who was a fellow at NIH and she hooked me up.
Thank you for the encouragement and here's hoping I at least have some response.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

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susie0915
Posts: 872
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: NIH trail update .. my T cells are growing!!

Postby susie0915 » Wed Aug 08, 2018 8:42 am

Such good news.
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoidoscopy/only scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod
7/17 no change lung nod
10/17 Clear pel/abd CT
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, clear CT pel/abd/lung nod no change
11/18 CEA .6

DAS43
Posts: 51
Joined: Thu Aug 18, 2016 8:10 pm

Re: NIH trail update .. my T cells are growing!!

Postby DAS43 » Wed Aug 08, 2018 10:30 am

Great news. I will be sending prayers your way. Grow cells! Grow!
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

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peanut_8
Posts: 2315
Joined: Sun May 25, 2014 1:31 pm
Location: Capital of Texas

Re: NIH trail update .. my T cells are growing!!

Postby peanut_8 » Wed Aug 08, 2018 10:36 am

Hooray!!
Terri aka peanut
diagnosed Jan 14, RC stage 2a, age 56
permanent colostomy
MSS
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED

sdino
Posts: 64
Joined: Tue Mar 28, 2017 5:32 pm

Re: NIH trail update .. my T cells are growing!!

Postby sdino » Wed Aug 08, 2018 11:53 am

Great news teri3 ! Cells are growing ! Has NCI/NIH determined Reactivity of your cells ? Best wishes !
Caregiver for Wife 53 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-1.8CM
MSS, KRAS-mutG12D; TP53
Folfox/Avastin+Oxi 11/16 to 5/17, Xeloda+Avastin 8/17
CT Scans: 5/17 colon & lung met shrinkage,11/17 and 1/18 slight progression; 5/18, 7/18 stable lungs/colon; 10/18 very slight progression
NCI YOUNGER TIL Trial NCT03412877 awaiting progression - 1/18 VATs lung 2 mets wedge resect
CEA:16-11/16; 0.6-5/17; 3.0-11/17; 4.2-2/18; 4.9-3/18; 4.0 - 5/18, 6.8-7/18; 5.1-9/18; 5.4-10/18

teri3
Posts: 396
Joined: Fri Jan 09, 2015 11:03 am

Re: NIH trail update .. my T cells are growing!!

Postby teri3 » Wed Aug 08, 2018 1:02 pm

Thanks everybody for the good wishes. They are starting testing for the reactivity this week I believe. They seemed pretty positive do I'm taking that as a good sign. I know I'm not in the clear yet but it's a start. :)
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

User avatar
Sleen
Posts: 313
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: NIH trail update .. my T cells are growing!!

Postby Sleen » Wed Aug 08, 2018 1:06 pm

I'm so glad to read this!!! Good luck to you! I look forward to your updates :)

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

Lee
Posts: 5740
Joined: Sun Apr 16, 2006 4:09 pm

Re: NIH trail update .. my T cells are growing!!

Postby Lee » Wed Aug 08, 2018 1:19 pm

Sleen wrote:I'm so glad to read this!!! Good luck to you! I look forward to your updates :)

Celine


Me too!! CONGRATULATIONS

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

teri3
Posts: 396
Joined: Fri Jan 09, 2015 11:03 am

Re: NIH trail update .. my T cells are growing!!

Postby teri3 » Wed Aug 08, 2018 2:01 pm

Thanks Celine. You and your hubby encouraged me even before you got into the trial and I thank you.
Thanks Lee fingers crossed it goes well. If not NIH has other things up their sleeves.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

NHMike
Posts: 1838
Joined: Fri Jul 21, 2017 3:43 am

Re: NIH trail update .. my T cells are growing!!

Postby NHMike » Wed Aug 08, 2018 3:56 pm

You are making history and may help to make cancer treatment easier for the next generation.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

User avatar
Shana
Posts: 401
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: NIH trail update .. my T cells are growing!!

Postby Shana » Wed Aug 08, 2018 5:09 pm

Great news! Wishing you all the success in the world!
DX - 12/16
MSS - KRAS wild
Well-differentiated adenocarcinoma at splenic flexure
Stage IV CC with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17
Irinotecan and Erbitux ran it's course. CEA rising
Primary tumor invaded tail of pancreas and spleen. Liver mets major concern
Y-90 radioembolization on 9/17/18, liver enzyymes have dropped. 10 Radiation treatments to primary tumor completed too. CT scan Nov to assess overall situation...


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