Pyro wrote:Well, had my first CEA test after 3 weeks of Keytruda, it went from 10 to 30, it's usually a good marker for me. Here is hoping it's psuedo progression!
boswind wrote:Pyro wrote:Well, had my first CEA test after 3 weeks of Keytruda, it went from 10 to 30, it's usually a good marker for me. Here is hoping it's psuedo progression!
Thank you for the info. I think it is psuedo progression.
I had first Keytruda infusion on Mar 14. I will have the CEA test on Apr 4 the day when I get the second Keytruda infusion.
boswind wrote:@Pyro I have the same concern as you do. I am willing to have Ketruda because I am against walll; no good alternatives remaining to me. I wish for the best.
I searched info about psuedo-progression on line, and found it is not based on variation of the CEA; it is based on variation of tumor size and the symptoms. Simply speaking, during a chemo drug is newly applied, if after the tumors initially become larger and/or the number of tumors increases then the tumors shrink and/or some of them disappear, we say it is a psuedo progression.
If your old CEA stayed stable, after Keytruda started your CEA had a large jump, most likely Keytruda is working. As we know, elevated CEA is largely due to dead tumor cells. When Keytruda is killing tumor cells, more dead tumor cells in our body, which resulted in a jump in the CEA level. We call it CEA flares ?
boswind wrote:@Pyro I read the following article posted on onclive.com:
https://www.onclive.com/publications/On ... -biomarker
It indicates TMB will be an challenging immunotherapy biomarker. Oncologists do not know if a specific patient with high TMB will respond do a PD-1/PD-L1 immunotherapy drug, although for a type of cancer the group with highest TMB has a highest response rate.
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