Keytruda....Working for MSS....Mutation Burden is the Key

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Jack&KatiesMommy
Posts: 515
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Postby Jack&KatiesMommy » Thu Aug 30, 2018 8:11 am

Steph20021 wrote:Thanks Dionca, I don’t know why foundation one quoted me more- unless cost has gone up or she quoted me for a different test. Either way I can’t afford it. So my plan is that I will start with getting a test done through a trial at PMH. I’ll speak with my oncologist tomorrow about it.
Hoping I can get a current biopsy done of a tumour I have now rather than my 4.5 year old banked stuff. I’ve done a lot of chemo since then.

Dionca wrote:
Steph20021 wrote:I wonder, can Canadians get Foundation One testing? What exactly am I asking them for, (just for “mutation burden testing of my tumour”) and how much could I expect to pay, any ideas?


Steph - here is a recent article posted on Colorectal Cancer Canada, that makes reference to the Foundation's mutation burden testing. It says the test is $5,800.

"All Cancer Patients Should Have Access To Genomic Testing"
http://archive.colorectalcancercanada.c ... ting/,5275
The novelty of Foundation’s approach—like that of a few other companies leading the field of cancer diagnostics—is the scope of testing. These laboratories examine hundreds of genes by a method called next-generation sequencing (NGS). For a price of $5800, in two weeks’ time, Foundation reports on tumor mutation burden (TMB), microsatellite instability (MSI), and mutations in any of 324 genes that may indicate sensitivity—or resistance—to oncology drugs.


Steph & Dionca:
You can apply for Financial Assistance....Foundation One is very generous in its application of the criteria. I am a lawyer and we are financially very comfortable. But when I applied I listed my dependents and my medical bills, house mortgage, cars, etc. and my financial responsibility was reduced by 60%. I would suggest that you call Foundation One and ask about this potion.
Cynthia
Cynthia
Mommy to Jack (8) now (15) and Katie (4) now (11)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection!
8/13; 10/13; 12/13; 3/14; 8/14; 11/14; 2/15; 7/15; 12/15 RFA lungs
5/17: Upper Left Lobe of lung resected.
02/18: 3 new mets lymph nodes in hilar/lung:
05/18: Started Keytruda (MSS but moderate mutation burden): CEA: 66.4, 39.2, 23.8, 13, 3.5 NOW 1.8
08/18 Clear CT scan

boswind
Posts: 40
Joined: Fri Apr 11, 2014 12:04 pm

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Postby boswind » Mon Sep 10, 2018 1:50 pm

When I was seen by my oncologist last week, I mentioned to him the tumor mutation burden and possibility of MSS patient responding to Keytruda. He said he would put me on a study program immediately and I would be tested extensively regarding gene mutation. If I have "right" mutations, I will be given Keytruda right away. Furthermore, the study program will pay for the cost of all gene mutation testing.
01.24.2014 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.2014 Completed 5-week Radia+Xeloda
05.07.2014 Had surgery
02.25.2015 CT showed liver and L4 Spine involvement.
03.2015 - 08.2015, folfox + Avastin
08.2015 - 07.2017, 5FU + leucovorin + Avastin for Maintenance
07.2017 - 01.2018, Folfuri + Avastin
01.25.2018 - present, Centuximab + Irinotecan
70 rounds of chemos received (as of 03.2018)
Current CEA: 5.7
MSS, KRAS wild type, BRAF wild type

User avatar
Jack&KatiesMommy
Posts: 515
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Postby Jack&KatiesMommy » Tue Sep 11, 2018 10:08 am

boswind wrote:When I was seen by my oncologist last week, I mentioned to him the tumor mutation burden and possibility of MSS patient responding to Keytruda. He said he would put me on a study program immediately and I would be tested extensively regarding gene mutation. If I have "right" mutations, I will be given Keytruda right away. Furthermore, the study program will pay for the cost of all gene mutation testing.


That is great! Where are you seen? This I great news for anyone in your area that is MSS. I'll keep my fingers crossed that you have a solid mutation burden. Please come back and let us know.
Cynthia
Cynthia
Mommy to Jack (8) now (15) and Katie (4) now (11)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection!
8/13; 10/13; 12/13; 3/14; 8/14; 11/14; 2/15; 7/15; 12/15 RFA lungs
5/17: Upper Left Lobe of lung resected.
02/18: 3 new mets lymph nodes in hilar/lung:
05/18: Started Keytruda (MSS but moderate mutation burden): CEA: 66.4, 39.2, 23.8, 13, 3.5 NOW 1.8
08/18 Clear CT scan


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