The Colon Club

Hi ,
They use a similar combination with stage 4 lung tumours and one chemotherapy is platinum based . You might like to check out some of their forums .

My friend has had an amazing response. She had Keytruda along with two chemo agents and one was a platinum based one . She had four cycles with everything then dropped the platinum one for a further two cycles . Now just Keytruda.

It was rough , but she has functioned throughout and still doing things for her three children. One has a learning disability so she has a lot to do .

The results have been incredible . Most tumours have resolved and the rest continue to shrink at an encouraging rate . She said the research for lung cancer is showing a better response if combined with chemo at the start . Not read any of it myself but you might like to have a look .

Take care ,

Stu

I’m aware of combination of chemo immunotherapy in other cancer types, but I don’t think that’s an approved therapy yet for CRC. Who is the doctor that is suggesting this?

Also are you sure he will prescribe FOLFOX again if you’ve already suffered neuropathy? How many rounds of FOLFOX have you completed? It seems more likely he would start you on FOLFIRI.

Hi all,
There is trial for chemo immunotherapy for crc:
http://clinicaltrials.gov/show/NCT02375672
I’m not qualified to participate due to my disease is not measurable. Both onc at MGH and Dana suggested this treatment. I had 12 sessions of Folfox + Avastin last year. This year I have 4 sessions of folfiry before the surgery but folfiry didn’t work well since the cancer still spreading.
My onc just called me today, he said there is trial with vaccines + immunotherapy that he will try to put me in due to my neuropathy but again, the same issue of qualification as my disease is not measurable. I’m hoping mri will show the spread in ileum. I will see my onc this Friday to discuss about this new option.
Foundation One test is scheduled and hopefully the results will come back before my first treatment.
B.t.w: per my onc, MGH will have in house ctDNA in a few weeks.
Thanks, Tina.

May I ask how your disease can be considered "not measurable" if you have peri mets that show on a CT scan?

During the surgery, the surgeon saw a lot of black plaques which are .5 to 1mm in size that spreads out in my ileum thus not resectable and pathology proved they are cancerous. The ct scan after surgery did not show these plaques and my current cea is 2.1. It is a matter of time these plagues will grow so Doctor want to treat it aggressively while it’s still early.

Based on the CT report and continuously rising CEA, my oncologist said Keytruda did not work on me. So I have to return to traditional chemos. I am now still in hospital to complete infusion of FOLFOX + Bevacizumab.

boswind wrote:Based on the CT report and continuously rising CEA, my oncologist said Keytruda did not work on me. So I have to return to traditional chemos. I am now still in hospital to complete infusion of FOLFOX + Bevacizumab.

Well fudge.

tbtsnow, is there any chance they would show up on an MRI?

boswind, sorry to hear that. Is your onc sure that 3 months is long enough to tell?

Boxhill, I had MRI done today. I will know in couple of days if it pickups those plagues. If it does then there will be biopsy to get tumor tissues for vaccines. If not, I will move forward with Folfox + Ketruda.
Boswind, I hope you get good results with this new regime. I guess we have to keep trying until we find something that works. Good luck.

Anyone know if the number of mutations increases after going through several different drugs? My mom had one mutation (KRAF?) back in 2015 when a biopsy was done.

meatie wrote:Anyone know if the number of mutations increases after going through several different drugs? My mom had one mutation (KRAF?) back in 2015 when a biopsy was done.

It’s not measurable/predictable like that, ask your oncologist to have it tested.

meatie wrote:Anyone know if the number of mutations increases after going through several different drugs? My mom had one mutation (KRAF?) back in 2015 when a biopsy was done.

The jury is still out on this one. Caris just released a study for lung cancer that suggests chemo or radiation does not significantly increase TMB.

Impact of prior chemotherapy or radiation therapy on tumor mutation burden in NSCLC
https://meetinglibrary.asco.org/record/172774/abstract

Just got an email from the doc, Keytruda didn’t work for me.

Sorry to hear that .

Stu

I'm so sorry Boswind & Pyro. I always kept going thinking that the longer I stuck around the more new treatments would be available....I have been fighting this disease for 8 years in August and I have seen 3 new breakthroughs and I think there are more just on the horizon.
Cynthia