mpbser wrote:I saw that thread about tumor burden. That's very exciting and great news.
I don't have details about our family friend but I hope that there are future developments for people with MSS and moderate tumor burden. For example, my husband's tumor had three mutations which would make him ineligible for the trial.
First, I wasn't in a trial at all. My oncologist got Keytruda approved off-label in order to see if it would work for me (due to having 11 mutations.) I don't know if the 3 mutations would be enough or not. But I wouldn't assume that it wouldn't work for your husband. My oncologist believes that cancer patients' cancer mutates the longer we live with it and the more treatments it is subjected to. So, for me, it may have taken all of these treatments, and time living with this cancer, to get it to a point that the immunotherapy would work. So, perhaps, if your husband needs it in the future, you can keep the idea in your head...have the tumor retested to see what mutations he as at that time. In the alternative, the three may be enough to open his cancer up to the immunologic drugs....
Mommy to Jack (8) now (17) and Katie (4) now (13)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection
8/13-12/15 (10) RFAs lungs
5/17: Upper Left Lobe of lung resected.
02/18: 3 new lymph mets lung
05/18: Keytruda (MSS w/Intermediate TMB): NED CEA: 66.4, 39.2, 23.8, 13, 3.5 1.8, 1.0, 2.8 3.9, 5.0, 5.6, 1.5, .8,