HELP.....Oxaliplatin allergy

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Eleda
Posts: 327
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

HELP.....Oxaliplatin allergy

Postby Eleda » Tue Jul 24, 2018 4:47 am

I'm having my second infusion of FOLFOX and because of my bad reaction to the throat sensation they have decided that I'm allergic to oxliplatin and only giving 5FU today and not willing to try oxliplatin again because of fear of anaflectic reaction,,,,
I could just about cry but in n a room full of other people getting chemo,,,,
I e begged to b admitted as an inpatient to try again but they said it's too dangerous,,,
I'm sorry I told them about my symptoms now :cry:
What am I going to do now????
They say it's life threatening if they give it
I say it is if they don't,,, I'm only 47 with three small kids, I wanted to go at this hard,,and now I feel I am reducing my chances because I had lymph node invoment
ADELE
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

Mercy110
Posts: 114
Joined: Wed Aug 16, 2017 12:13 am

Re: HELP.....Oxaliplatin allergy

Postby Mercy110 » Tue Jul 24, 2018 9:23 am

So sorry to hear that but I think they are right not to continue with oxaliplatin. My mum had similar allergic syndrome on her 10th chemo of folfox. It is life threatening.

It is difficult to accept stopping folfox at once, but it is more important to ask for aggressive treatments other than folfox. I think Folfiri is another common chemo combination replacing folfox. Don’t give up. Prayers to you and your family.
My Mum (age 56), NRAS-mutate Q61R
2017-05: Surgery with stoma. T4N1M0. Stage3C. Xeloda Only. Increasing CEA. CT: Multiple lung nodules. Stage4.
2017-09: 85% FOLFOX + Avastin, stable CT
2018-03 to 05: Folfox Allergy, Folfiri (with Avastin since Oct)
2019: CEA:178, started Irinotecan+Zaltrip+TS-1, 25 times radio with xeloda
2020: CEA: 217.3, pending treatment


WISH ALL MIGHTY GOD HEALS MUM WITH HIS MIRACLE

Ehut
Posts: 220
Joined: Wed Sep 26, 2012 4:24 pm
Location: Algonquin, IL

Re: HELP.....Oxaliplatin allergy

Postby Ehut » Tue Jul 24, 2018 10:05 am

I had the allergic reaction to Oxaliplatin at my 5th or 6th infusion. They finished that infusion with just 5FU, Leucovorin, and Avastin. The remaining cycles were with Folfiri. The way my oncologist explained it, the 5FU does 90% of the work. The Oxaliplatin or Leucovorin only helps a little bit.
Dx 12/11 rectal stage IV w/ 6 mets to liver, age 35
4 cycles FOLFOX 12/11 to 2/12
short course radiation 2/12
rectal/liver resection 3/12, temp ileostomy
8 cycles FOLFOX/FOLFIRI 4/12 to 8/12
ileostomy reversal 10/12
port out 10/13
NED for 7+ years and counting!

Beckster
Posts: 421
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: HELP.....Oxaliplatin allergy

Postby Beckster » Tue Jul 24, 2018 10:35 am

Eleda wrote:I'm having my second infusion of FOLFOX and because of my bad reaction to the throat sensation they have decided that I'm allergic to oxliplatin and only giving 5FU today and not willing to try oxliplatin again because of fear of anaflectic reaction,,,,
I could just about cry but in n a room full of other people getting chemo,,,,
I e begged to b admitted as an inpatient to try again but they said it's too dangerous,,,
I'm sorry I told them about my symptoms now :cry:
What am I going to do now????
They say it's life threatening if they give it
I say it is if they don't,,, I'm only 47 with three small kids, I wanted to go at this hard,,and now I feel I am reducing my chances because I had lymph node invoment
ADELE


I had an anaphylactic reaction to oxi on my first infustion..... not fun! Thank God I was there when it happened. It hit me when I was leaving.
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda monotherapy
6/17,12/17,6/18,12/18, 6/19, 12/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0
Clear Colonoscopy 10/17, 11/19 :D

Eleda
Posts: 327
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: HELP.....Oxaliplatin allergy

Postby Eleda » Tue Jul 24, 2018 11:13 am

Thanks guys
I'm still on FLUOROURACIL pump and leucovorin)
But I feel like my holy grail of drug has been pull from under me, I I'm just will to put up with anything for the best chance of a good outcome, Which I know dying of anaphylaxis is obviously stupid but I think it's a reaction to the drug ( side effect) and not an allergic reaction
Adele X
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th

CLD
Posts: 206
Joined: Fri Mar 27, 2015 7:16 pm

Re: HELP.....Oxaliplatin allergy

Postby CLD » Tue Jul 24, 2018 1:02 pm

My husband developed an allergy to oxaliplatin. The oncologist gave him IV Benadryl and he was able to continue all 12 cycles, last 2 were reduced due to neuropathy. He slept the whole time, and was not permitted to drive himself home, but that worked for him.
Wife to DH/ Father of 6 (age 42 at dx) diagnosed Jan 2015 stage IIIC
Tumor deposit in mesentery 13/24 lymph nodes +
CEA at dx: 5
MSS
Low Grade/Mod. Diff.
FOLFOX 6 months
N.E.D until June 2018
PET Scan 6/18
Biopsy confirms cancer in 3 Paraaortic lymph nodes
Folfiri + Avastin (6tx) and Xeloda during radiation
Cancer all over both lungs dx Jan 2019
FOLFIRI +AVASTIN presently

Eleda
Posts: 327
Joined: Thu Dec 28, 2017 2:28 am
Facebook Username: adele Morgan
Location: Ireland

Re: HELP.....Oxaliplatin allergy

Postby Eleda » Tue Jul 24, 2018 1:15 pm

I've just read a protocol for desensitizing to oxliplatin so I'm hoping he'll go for it, and add in the antihistamines prior,,, I really want to do this so I'll try anything and deffinatly suggest the benadryl thanks
I was planning on taking my CBD and sleeping through this round because I knew what to expect

I'm still hopeful,, I'll know next week after my meeting with the oncologist, and my next session was put off for an extra week because the appointmenta aren't available in two weeks time ( such bullshit) I'm annoyed at everything ATM lol
Thanks again for all the replys
Adele X
SWF, 47
Mom to 3 sons 6/8/12
Dec4th 2017 colonoscopy for minor intermittent rectal bleeding during Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV.
JAN 3RD started 1650mg Zelda 2xday, with 28 radiation
Did tagamet 800mg daily and 75mg IV VIT C WEEKLY UNTIL SURGERY and
Tumor reduce by 80% 1 LN still remaining
TATME May10th, temp illeostomy
10/07/2018 CEA 3
MMR INTACT
Began FOLFOX July 10th
24/08/2018 Allergic reaction so next infusion lucovorin and 5fu
CEA 4
Second attempt with oxi aug 12th


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