Signet Ring Cell colon cancer is rare, like 0.5-2%. So colorectal cancers with SRC components fundamentally have less familiarity and experience.
The papers I've read indicate it is often highly mutated including BRAF. I would definitely want MSI and KRAS/BRAF genetic profile information. I would post as much information (right/left, MSS-MSI, KRAS/BRAF, bloodwork CEA, CA199, LDH, MCV and CBC changes from diagnosis to present) as possible - to try to attract any other SRC experience specifically, and any biomarker or experience parallels generally.
To my mind, in your situation, I would look at two approaches to try to get ahead - either some PL1 checkpoint inhibitor combination for MSI-H (attack the microsatellite instability) or to attack a BRAF/KRAS mutation with a continuous application of mild/oral 5FU drug, a CRC stem cell inhibitor(s) (e.g. celecoxib/Celebrex and/or CA199 targeted cimetidine), IV vitamin C (for BRAF/KRAS mutants), and combinations of natural adjuncts. Natural adjuncts may help attack the cancer cells' specific weaknesses, as well as rebuild parts of your body, blood and immune components.
watchful, active researcher and caregiver for stage IVb/c CC since early 2010. surgeries 4/10 & 5/11; 8 yrs immuno-Chemo for mCRC, now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher