Chemotherapy and radiotherapy have some cumulative risk for dysplasia and leukemia. Chemo for CRC is not considered especially problematic although there is a tendency to not much acknowledge common treatment dysplasias either. Other problems have historically been considered more critical.
A Colon Club forum member who has discussed CML is Traci43, at CSN these days. It is a problem to distinguish de novo chronic leukemia from treatment related chronic leukemia and it has pretty low coverage in the literature. With acute leukemia drs do routinely distinguish between treatment related and de novo acute leukemia.
In the medical literature there are long term upper MCV values that associate with later risk of treatment related leukemia, particularly some drugs for other cancers. MCV is a consideration in chemo intensity for us, upper (leukemia risk) and lower (to be active enough against cancer). In my wife's immunochemo regimen, things that are described to ameliorate some dysplasias and leukemia cells include natural folate sources, PSK (a special hot water Coriolus mushroom extract), the human form of vitamin K2 (menatetrenone aka menaquinone-4), and IV vitamin C.
watchful, active caregiver for stage IVb CC since early 2010. immuno"Chemo forever," for mCRC