emkaye wrote:My chief concerns are:
a) Should we get a 2nd opinion (we do really like this guy and he is VERY thorough)
b) Has anyone else done OXALPLATIN for Stage II?
c) Can we or SHOULD we have the tissue sent anywhere else (like a major cancer center) don't know if this is possible
retiredteacher wrote:Was this rectal or colon?
Terri
SurvivorsSpouse wrote:This looks like the tumor was a T3 and 3mm from the anterior abdominal wall adhesion. I don’t see where it says the tumor itself adhered to the wall.
This would place the stage at 2A, which is questionable when it comes to chemo. The distance of 3mm from the margin and Grade 2 (moderate) might push this into the realm of chemo.
Deb m wrote:Yes it is possible to send everything to a major cancer center. By everything I mean, all scans, e-rays, colonoscopy results, pathology results, blood work. When they remove the tumor, they place it in slides and what they call blocks. These can also be sent to a major cancer center. Hospitals usually preserve and keep them so they should have them for you to send. A major cancer center will do their own pathology on all the tissue removed from you and come to their own conclusion. Usually you just need to notify the hospital where everything was done, and tell them where you want it all sent to and they will take care of it. I would recommend MDA, where we went or Sloan Kettering in New York, the Mayo clinic, Fred Hutchinson center in Seattle Washington. There are some others as well, but I think any of those would be good.
deb m
emkaye wrote:Deb m wrote:Yes it is possible to send everything to a major cancer center. By everything I mean, all scans, e-rays, colonoscopy results, pathology results, blood work. When they remove the tumor, they place it in slides and what they call blocks. These can also be sent to a major cancer center. Hospitals usually preserve and keep them so they should have them for you to send. A major cancer center will do their own pathology on all the tissue removed from you and come to their own conclusion. Usually you just need to notify the hospital where everything was done, and tell them where you want it all sent to and they will take care of it. I would recommend MDA, where we went or Sloan Kettering in New York, the Mayo clinic, Fred Hutchinson center in Seattle Washington. There are some others as well, but I think any of those would be good.
deb m
The oncologist is already ordering the oncotype testing. If I order a secondary pathology report as well is this possible or can the specimen slides only be sent out to one location?
The biopsy is a block and it should be at the hospital where you had it done. They may use some of it up for the first pathology test. If there's enough leftover, it can be sent to another lab or hospital to do the Genomic Tumor Testing (Onctotype DX in your case). I had this done - my biopsy was taken during a colonoscopy and was at the hospital where the colonoscopy was done. My son's boss offered to do the Genomic Tumor Testing and I just had to fill out a form providing permission for them to request it. They requested the block and it was sent over and they did the testing on one of their Next Gen Sequencing Machines and his boss did the report for me.
emkaye wrote:The biopsy is a block and it should be at the hospital where you had it done. They may use some of it up for the first pathology test. If there's enough leftover, it can be sent to another lab or hospital to do the Genomic Tumor Testing (Onctotype DX in your case). I had this done - my biopsy was taken during a colonoscopy and was at the hospital where the colonoscopy was done. My son's boss offered to do the Genomic Tumor Testing and I just had to fill out a form providing permission for them to request it. They requested the block and it was sent over and they did the testing on one of their Next Gen Sequencing Machines and his boss did the report for me.
Thanks, I have a call into the office and am waiting for a call back from the doctor to see about further pathological testing. The woman who I spoke to made it sound like "no one ever asks for a second pathological review." She seemed to think that the oncotype testing would be considered a secondary opinion however, oncotype is looking for genetic markers and not the tissue pathology itself. I hope I can get this done. Crossing fingers and saying a prayer.
“...Moreover, MMR or MSI testing is recommended by the NCCN for all patients with stage II CRC, based on the results obtained by Sargent et al. suggesting that patients with dMMR tumour receiving FU-based therapy may receive no benefit from adjuvant systemic therapy...”
Reference: http://www.mdpi.com:8080/1422-0067/18/1/107/pdf(“Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients”)
Sargent, D.J.; Marsoni, S.; Monges, G.; Thibodeau, S.N.; Labianca, R.; Hamilton, S.R.; French, A.J.; Kabat, B.;Foster, N.R.; Torri, V.; et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluoruracil-based adjuvant therapy in colon cancer.
J. Clin. Oncol. 2010, 28, 3219–322
Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”
Users browsing this forum: Google [Bot] and 359 guests