Low Platelets

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boxhill
Posts: 40
Joined: Fri Apr 06, 2018 11:40 am

Low Platelets

Postby boxhill » Tue Jun 12, 2018 6:59 pm

Despite feeling great, I wasn't able to be infused for Round 4 today. My platelets had sunk from 104 last time to 63. My WBC has gone down to 2.4 (I started out at 2.9), but it's the platelets that have taken a nose dive from a starting point of 179.

I told them I wanted to power on through if at all possible, but the oncologist said no way. If the platelets went down further after this treatment I could be in serious trouble. So my infusion is being put off for a week, and they are considering reducing the oxaliplatin dose going forward.

I'm frustrated, and worried that I won't derive maximum benefit with a lower dose. But it appears that there is basically nothing I can do to bolster the platelet production.
F, 64 at DX CRC Stage IV (or "3 1/2" per Dana Farber consult, LOL)
3/17/18 blockage, emergency surgery, r hemicolectomy
11 of 25 nodes
5 of 5 mesentery nodes, matted
0.5 cm sub-capsular liver met removed
pT3 pN2b pM1
Neg CEA, neg BRAF, mut KRAS, germline mut ATM
dMMR, MSI-H, Neg for Lynch
5/4/18 FOLFOX

DebZ
Posts: 80
Joined: Fri Nov 14, 2014 9:01 pm
Facebook Username: Bulc

Re: Low Platelets

Postby DebZ » Tue Jun 12, 2018 9:16 pm

My new norm for platelets is low 50s and I still get chemo. My oxali is around 60 to 70 % strength, and we have to stretch it out to every three weeks. We've been tossing around different things to try to get the platelets up because it's a real concern. Disqualifies me from some trials.
48 @ diagnosis Sept 2014
MSS; Kras mutant G12D
Oct 2014: right hemicolectomy
Dec 2014-May 2015: Folfox
June 2015: clean scans
Sept 2015: scans reveal ovarian mass and liver met; Folfiri
Jan 2016: liver wedge resection and hysterectomy
April 2016: multiple lung mets; Folfiri+Avastin
June 2017: lung mets growing; switch to Folfox+Avastin
Jan-April 2018: dropped oxali; CEA rising
May 2018: back on Folfox+Avastin, add pulse steroid treatment to get platelet count up (continuously in 50s)

boxhill
Posts: 40
Joined: Fri Apr 06, 2018 11:40 am

Re: Low Platelets

Postby boxhill » Wed Jun 20, 2018 8:12 pm

And this week it's neutrophils! Down to 0.7, won't treat under 1.0, afraid chemo today would push it below 0.5 and I would be open to potentially serious bacterial infections. I'm willing to risk it, but my oncologist isn't.

My platelets are back up to 175, my hematocrit has just edged up into the normal zone for the first time at 34.6, and Hgb is the highest it's been, at 11.8. The ANC was probably even lower last week, I'm told, which may be why I had a sore throat starting Thursday that went away on Monday.

Now the plan is to go back Tuesday and hope it has recovered enough. I'll receive a prophylactic shot of Neulasta on Thursday when they remove the pump. He plans to reduce the dose of Oxi, and/or possibly the bolus of 5FU. My bone marrow just isn't cooperating.

I am SO frustrated. This means I will have missed a full 2-week cycle. And I feel fine. I get all geared up for the infusion and the pump, go in, and nada. I'm trying to be philosophical, but failing. It is such a roller coaster.
F, 64 at DX CRC Stage IV (or "3 1/2" per Dana Farber consult, LOL)
3/17/18 blockage, emergency surgery, r hemicolectomy
11 of 25 nodes
5 of 5 mesentery nodes, matted
0.5 cm sub-capsular liver met removed
pT3 pN2b pM1
Neg CEA, neg BRAF, mut KRAS, germline mut ATM
dMMR, MSI-H, Neg for Lynch
5/4/18 FOLFOX

Aqx99
Posts: 399
Joined: Fri Mar 31, 2017 7:28 am
Facebook Username: aqx99
Location: Pfafftown, NC

Re: Low Platelets

Postby Aqx99 » Fri Jun 22, 2018 11:30 am

I know how you feel. My final cycle of chemo had to be delayed twice because my platelets were too low. The first week they were at 78, the second they dipped to 69, then when I went back the third week they were just at 100.
Anne, 40
Stage IIIB Rectal Cancer
T3N1bM0
2/21/17 Diagnosis, Age 39
2/21/17 CEA 0.9 ng/mL
3/23/17 - 5/2/17 Chemoradiation, 28 treatments
6/14/17 Robotic LAR w/temp loop ileostomy, ovaries & fallopian tubes removed, 2/21 lymph nodes positive
7/24/17 - 12/18/17 CapeOx, 6 Cycles
7/24/17 Diagnosed w/ovarian cancer
9/6/17 CA 125 11.1 U/mL
11/27/17 CEA 2.6 ng/mL
12/5/17 CT showed NED
12/13/17 CEA 2.9 ng/mL
1/11/18 CA 125 8.6 U/mL
1/23/18 Reversal
3/21/18 CT showed enlarged thymus
4/6/18 PET confirmed NED

mobrouser
Posts: 17
Joined: Wed Apr 11, 2018 1:44 pm
Location: Ontario

Re: Low Platelets

Postby mobrouser » Fri Jun 22, 2018 10:18 pm

I have posted here previously about my platelet and neutrophil issues. My oxaliplatin was reduced to 90% for round 3, and has been at 75% since round 5.
I just completed round 9 last Friday and I am 6 weeks behind schedule because of low counts. It is a constant in the back of my mind that all of this could be increasing the potential for mets to develop.
I console myself with the fact that I started off with no mets, and have done everything the doctors have asked of me to get through the treatments.

Prior to round 8 I was prescribed Grastofil, the generic version of Neupogen, to help with my neutrophil levels as even with the oxali reductions my platelet and neutrophil levels were tanking each round.
I give myself daily injections for 7 days following completion of each round. One of the side effects is bone pain. I was pleasantly surprised to find that so far I have not had any.
The preferred injection site is the lower abdomen, but I have been doing it in the upper thigh area and found that the skin there is less sensitive so there is no pain inserting the needle.
I am also on daily blood thinner injections, even with my platelet issues, so my abdomen is so sore from 6+ months of those daily injections.
But I have to believe that I will get through this with flying colours. And you will too!!!

8) mob
CC Dx Oct 2017 @ age 58
Laparoscopic hemi-colectomy Dec 2017
Adenocarcinoma ascending colon – 6cm x 6cm x 2cm, Low Grade, penetrates to peritoneum
T4a N2a M0, Stage IIIC
lymph nodes 6 positive out of 18
FOLFOX started Jan 16 2018


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