anyone here with Kras T53 mutation

[NHMike]

https://www.forbes.com/sites/victoriafo ... st-cancer/

This article mainly covers the case of a woman who was cured of Breast Cancer but it mentions the colorectal case as well.

[Jackar0e]

The Letters represent the amino acid substitution in the protein or in this case the Kras Gene. So for Kras G12D that is - in position 12 of the Kras Gene the normal wild type has a Glycine (Abbreviated G) that has been changed to an Aspartic Acid (abbreviated D) in the mutation. These two amino acids are very different in shape and as a result greatly effects the binding of inhibitors of KRAS. Kras G12D is the most common mutation of Kras but there are others. I believe about 30% of colon cancers have mutations in Kras.

Regards,

GrouseMan

Thank you so much that is very well put, My oncologist dose not seem hopeful. I looked at the letters and mine are G12S stupid ? but why the S and not the D?? they are trying one last chemo of oxy and 5FU then I guess clinical Trial I appreciate all the help I can get. We are the best advocates for ourselves

The KRAS G12S mutation arises from a single nucleotide change (c.34G>A) and results in an amino acid substitution of the glycine (G) at position 12 by a serine (S).

http://targetedcancercare.massgeneral.o ... S-(c-34G-A).aspx

Thank You, I dont have the mind to understand that..I know I sound stupid...But TY for the reply