anyone here with Kras T53 mutation

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NHMike
Posts: 1729
Joined: Fri Jul 21, 2017 3:43 am

Re: anyone here with Kras T53 mutation

Postby NHMike » Sat Jun 09, 2018 3:03 pm

https://www.forbes.com/sites/victoriafo ... st-cancer/

This article mainly covers the case of a woman who was cured of Breast Cancer but it mentions the colorectal case as well.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

Jackar0e
Posts: 10
Joined: Fri Feb 10, 2017 8:55 pm
Facebook Username: Amy Cremisio
Location: Waterford, NY

Re: anyone here with Kras T53 mutation

Postby Jackar0e » Sun Jun 10, 2018 9:28 am

NHMike wrote:
Jackar0e wrote:
GrouseMan wrote:The Letters represent the amino acid substitution in the protein or in this case the Kras Gene. So for Kras G12D that is - in position 12 of the Kras Gene the normal wild type has a Glycine (Abbreviated G) that has been changed to an Aspartic Acid (abbreviated D) in the mutation. These two amino acids are very different in shape and as a result greatly effects the binding of inhibitors of KRAS. Kras G12D is the most common mutation of Kras but there are others. I believe about 30% of colon cancers have mutations in Kras.

Regards,

GrouseMan



Thank you so much that is very well put, My oncologist dose not seem hopeful. I looked at the letters and mine are G12S stupid ? but why the S and not the D?? they are trying one last chemo of oxy and 5FU then I guess clinical Trial :( I appreciate all the help I can get. We are the best advocates for ourselves :)


The KRAS G12S mutation arises from a single nucleotide change (c.34G>A) and results in an amino acid substitution of the glycine (G) at position 12 by a serine (S).

http://targetedcancercare.massgeneral.o ... S-(c-34G-A).aspx

Thank You, I dont have the mind to understand that..I know I sound stupid...But TY for the reply
44yrs old /Female
DX: Rectal Cancer
Tumor Location: If RC lower rectum,colon
Tumor type: carcinoma,
Tumor size 13mm

G1: Well differentiated
Stage : Stage IV
Mets: Liver
Baseline CEA value
Lymphovascular invasion : present


KRAS +

Chemotherapy XELOX, CAPEOX, FOLFOX,


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