New study: beta-blockers (e.g. Propranolol) enhance immunotherapy?

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Tim UK
Posts: 71
Joined: Fri Jun 12, 2015 1:05 am

New study: beta-blockers (e.g. Propranolol) enhance immunotherapy?

Postby Tim UK » Tue May 29, 2018 9:45 am

http://news.psu.edu/story/497450/2018/0 ... ients-live

Does anyone (or their onc) have a view on this recent Penn State study? The summary is that in a retrospective analysis of patients on immunotherapy, those that were also on pan beta-blockers showed much higher survival rates (70% 5-year survival) than those not on beta-blockers (25%). The focus was on melanoma patients, but given the parallels in treatment between that and CRC I think it's interesting for people who, like me, are on atezolizumab, pembro, nivo etc.

Best wishes to all,
Tim
https://youtu.be/qoQbY4A5RNA
05/15 L hemi-colectomy - robotic, laparoscopic
05/15 Dx st 3 T4N2M0 @43
kids: 11,7
BRAFm mucinous - KRASw
06/15 2 liver mets
06/15 CEA 9, CA19-9 400+
06/15 - 09/15 6 x FOLFOXIRI+Avastin
09/15 markers 4/50
10/15 drain-site met
11/15 CRS+HIPEC
1-8/16 BRAF therapy (dabrafenib, panitumumab, trametinib)
CEA;CA19-9: 1/16 16;650 | 2/16 3;690 | 3/16 1;36 | 4/16 2;46 | 5/16 1;29 | 6/16 1;42 | 7/16 2;44 | 8/16 3;72 and 4;135
8/16 progression (PET)
10/16 Trial: NCT02650713

plastikos
Posts: 309
Joined: Wed Jan 14, 2015 6:09 am

Re: New study: beta-blockers (e.g. Propranolol) enhance immunotherapy?

Postby plastikos » Tue May 29, 2018 11:06 am

Interesting read. Thanks for sharing.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED

User avatar
LPL
Posts: 410
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: New study: beta-blockers (e.g. Propranolol) enhance immunotherapy?

Postby LPL » Tue May 29, 2018 11:59 am

Tim, Thank You! for sharing this info.
I am looking for a good Forum (like ColonClub) with info for a friend, her DH has just been diagnosed with Melanoma. It looks like I can find valiable info for her right here!
Again, Thank you <3
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED for now :D
:!: Steroid induced hyperglycemia dx after 3chemo .. hospitalized, insulin -> Metformin
Surgeries (open):
3/18 Emergency colostomy 5/23 Primary+gallbl+colostomy reversal (+port) 9/01 Liver mets


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