Pexa-Vec ... Trial Results

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Schallen
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Joined: Sun Mar 18, 2018 9:26 pm
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Pexa-Vec ... Trial Results

Postby Schallen » Thu May 17, 2018 8:38 am

Sillajen said Thursday that it has presented partial sections of its phase 1 clinical trial for Pexa-Vec, a solid cancer treatment, at the American Society of Clinical Oncology in Chicago.
According to Sillajen, the trial proved the safety and efficacy of Pexa-Vec on three patients with metastatic melanoma and five patients with liver metastasis colorectal cancer. The treatment also showed no severe side effects and high tolerance among patients. A high tolerance means that the side effects are so low that the patient can tolerate taking medicine.
The company also confirmed active Vaccinia virus infiltration inside the tumor tissues of patients, who underwent a single intravenous administration of Pexa-Vec before surgery.
A result of an analysis of peripheral blood sphere cells also showed an increase in the expression of CD69 (immune cell activation index) natural killer (NK) cells, antigen presenting cells (CD14 +), and T-cells (CD4 +, CD8 +).
“Such increased expression means that there is a strong activation in the immune cells,” a company official said. “The trial has proved that Pexa-Vec activates NK cells to spray granules containing immunotherapeutic agents when they interact with cancer cells.”
The study has also shown that the drug strongly promotes both innate immunity and acquired immunity, he added.


http://m.koreabiomed.com/news/articleVi ... idxno=3302

Geoman
Posts: 19
Joined: Sun Apr 29, 2018 8:48 pm

Re: Pexa-Vec ... Trial Results

Postby Geoman » Thu May 17, 2018 9:14 am

This reads like great news! I wonder if this is great news?
Dx @ 44, rectal cancer-stage 4 with Mets to liver 8/16
CEA 19
Kras g12d; Braf
Ypt3,ypN1a,ypM1
5 rounds 5fu with avastin (4) 9/16-11/16
PVE/Liver Resection 12/16
28 days rad/xeloda 2/17-3/17
APR-4/17
Clear Margins
7 rounds 5Fu with avastin- 5/17-8/17
CEA-1.2
NED-12/17, 1/18,
Multiple spots in lungs-5/18

User avatar
GrouseMan
Posts: 888
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Pexa-Vec ... Trial Results

Postby GrouseMan » Thu May 17, 2018 12:36 pm

Those interested in this technology might be interested to know that a Phase I/II clinical trial for people with MSS Metastatic CRC that have failed the other standard treatments is being conducted at NIH in Bethesda MD. Here is a link to the to the ClinicalTrials.gov web site:

https://clinicaltrials.gov/ct2/show/NCT03206073

Looks interesting. Wish it had been further along - say a year and a half as much, then perhaps I might have had a better trial to try and get my wife into. Came too late for her but maybe someone else here can benefit.

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

stu
Posts: 1613
Joined: Sat Aug 17, 2013 5:46 pm

Re: Pexa-Vec ... Trial Results

Postby stu » Thu May 17, 2018 5:58 pm

Thinking of you Grouseman .
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Pexa-Vec ... Trial Results

Postby NHMike » Thu May 17, 2018 6:18 pm

This, along with the other vaccine trial, provides a lot of promise and hope.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


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