Xeloda, Avastin, post nasal drip and a cough

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Xeloda, Avastin, post nasal drip and a cough

Postby recruiter » Wed May 16, 2018 3:15 pm

Anyone had trouble with this?

I have congestion balling up in the base of my throat. My nose runs like a river, inside and out. And late day, I find myself trying to cough the congestion up. It's worse now, with allergies part of the equation.

Any thoughts and advice?
DX Stage 4 2/16 with lung mets
4/16 CT, PET show "marked improvement" in size and number of lung mets, rectal tumor.
8/16 "Great report" from scans, lung mets continue to shrink in size and number, CEA 1.6, cancer "in remission" but surgeon believes tumor remains too large.
10/16 Xrays for constipation problems reveal tumor occupies 25 percent of rectal canal: Occupied 80 percent upon diagnosis 2/16
12/16 Back on Avastin; tumor can be removed, but need better margins.

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Re: Xeloda, Avastin, post nasal drip and a cough

Postby Lee » Wed May 16, 2018 3:35 pm

Not any real advice other than to follow up with you Onc. Could be nothing, butt a friend of mine came back from Israel, few days later ended up in the ER with breathing problems. Learned she had pneumonia. They believe she probably got the flu on the plane ride going home and then it turned into pneumonia.

good luck,

rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

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Joined: Wed Dec 30, 2015 11:29 am

Re: Xeloda, Avastin, post nasal drip and a cough

Postby crazylife » Wed May 16, 2018 6:43 pm

DH had the same after lung surgery. Coughing fits and a constant drip. Claritin helped a lot and luckily it’s not resolved.
Wife to DH, 41 years old, diagnosed 11/15
Stage 4, Mod diff, 13/24 LN, 1 liver met
Colon/liver resection at MSK, 11/15
8mm lung met (not confirmed) and enlarged lymph nodes 1/16
12 rounds of folfox (9 with Oxi) 6/16
NED - July 2016
NED - October 2016
3 lung mets - March 2017
7 lung mets, May 2017
RFA to largest met, June 2017
Lung mets growing slowly, October 2017 (off treatment since June 2016)
Right lung surgery, November 2017
Left lung surgery, January 2018
NED - May 2018

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Location: near DC

Re: Xeloda, Avastin, post nasal drip and a cough

Postby mhf1986 » Wed May 16, 2018 7:52 pm

DH has the same drip. We were told it's because of the decreased nose hairs, everything just flows out.
Caregiver to DH, dx @ 50, mets to liver/lungs, MSS, wild
9/16 CEA 114, blockage, left hemi, perm. colostomy
11/16 port in, FOLFOX + Avastin
6/17 CEA 15, 5FU + A only due to neuropathy
11/17 CEA 38, CAPOX + A
1/18 CAPOX = hi bilirubin/bad hfs, back to FOLFOX + A
5/18 growth; Vectibex + 75% Irinotecan
7/18 CEA 23, shrinkage
10/18 CEA 28, growth of 2 liver tumors/shrinkage of few and lung nodes
11/18 Lonsurf, looking at spheres, proton, trials
11/19/18 Peace

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Facebook Username: Betsy Lindh Williams
Location: Maryland - outside DC

Re: Xeloda, Avastin, post nasal drip and a cough

Postby betsydoglover » Sun May 20, 2018 12:12 pm

Avastin is known to cause nasal congestion, somewhat bloody nose, and post nasal drip. I stopped Avastin in April 2011 after 2 years, BUT I still have the mucous in the AM. My oncologist sent me to an allergist - total workup - no allergies. Don't want to scare you, but it may be something to live with. On the other it took nearly 2 years of Avastin for this to develop, so in the long run this may well not be along term issue.

Take care,
diag. Stage IV, 5/05, liver met
lap sigmoid colectomy, 6/05
6 cycles Xeloda/oxaliplatin/Avastin (NED after 2)
11/08 9x13mm right lower lobe lung nodule; removed via VATS 4/09
6 cycles Xeloda + Avastin
Avastin only 10/09-5/11
Still NED 06/18

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Re: Xeloda, Avastin, post nasal drip and a cough

Postby juliej » Mon May 21, 2018 5:51 pm

Bill, I had a runny nose with Avastin too. And you're right - spring allergies just add to the problem!

I also had nosebleeds from time to time, but mainly just saw blood in the Kleenex after I blew my nose. My onc recommended Afrin. It's an OTC spray used for allergies but is popular with Avastin patients because it prevents nose bleeds. Ask your onc if you can give it a try!

Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

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