Sustol Injection Pain

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boxhill
Posts: 115
Joined: Fri Apr 06, 2018 11:40 am

Sustol Injection Pain

Postby boxhill » Sun May 13, 2018 8:04 pm

I had this time-release anti-nausea injection at my first FOLFOX infusion on 5/4. I still have a painful lump, and in fact it has been hurting more and more in the last few days, sometimes when I'm not even moving or using my arm. (There are no signs of an infection.)

Since I have not had even a smidgen of nausea so far--Cycle 2 day is Thursday, four days away--I am thinking of refusing the shot this time. I certainly couldn't have it in the same arm, and I'm not keen on the idea of being in pain on both sides for who knows how long! I can always have it again Cycle 3 if I experience nausea that the so-far-untouched meds don't fix.

Has anyone else had this long-lasting, painful reaction to Sustol? How long did it take to go away? Anyone refused the injections?

I realize that this is kind of a "first world problem" in the realm of CRC. :wink:
F, 64 at DX CRC Stage IV (or "3 1/2" per Dana Farber consult, LOL)
3/17/18 blockage, emergency surgery, r hemicolectomy
11 of 25 nodes
5 of 5 mesentery nodes, matted
0.5 cm sub-capsular liver met removed
pT3 pN2b pM1
Neg CEA, neg BRAF, KRAS G12D, germline mut ATM
dMMR, MSI-H, Neg for Lynch
5/4/18 FOLFOX started
Added Neulasta 6/28/18
7/9/18 CT scans show no masses or enlarged nodes, 2mm indeterminate lung nodule

boxhill
Posts: 115
Joined: Fri Apr 06, 2018 11:40 am

Re: Sustol Injection Pain

Postby boxhill » Tue May 15, 2018 5:40 pm

Since no one seems to have had experience with this, I'm wonder if it is unusual for Sustol to be used at all.

Is there anyone here who was given it with their infusions? The other name for it is granisetron.
F, 64 at DX CRC Stage IV (or "3 1/2" per Dana Farber consult, LOL)
3/17/18 blockage, emergency surgery, r hemicolectomy
11 of 25 nodes
5 of 5 mesentery nodes, matted
0.5 cm sub-capsular liver met removed
pT3 pN2b pM1
Neg CEA, neg BRAF, KRAS G12D, germline mut ATM
dMMR, MSI-H, Neg for Lynch
5/4/18 FOLFOX started
Added Neulasta 6/28/18
7/9/18 CT scans show no masses or enlarged nodes, 2mm indeterminate lung nodule

Geoman
Posts: 19
Joined: Sun Apr 29, 2018 8:48 pm

Re: Sustol Injection Pain

Postby Geoman » Tue May 15, 2018 7:05 pm

Hi.

During my chemo, this drug was never mentioned. My nasua relief was zophran or phenigren.
Dx @ 44, rectal cancer-stage 4 with Mets to liver 8/16
CEA 19
Kras g12d; Braf
Ypt3,ypN1a,ypM1
5 rounds 5fu with avastin (4) 9/16-11/16
PVE/Liver Resection 12/16
28 days rad/xeloda 2/17-3/17
APR-4/17
Clear Margins
7 rounds 5Fu with avastin- 5/17-8/17
CEA-1.2
NED-12/17, 1/18,
Multiple spots in lungs-5/18

mhf1986
Posts: 139
Joined: Sat Mar 11, 2017 8:30 pm
Location: near DC

Re: Sustol Injection Pain

Postby mhf1986 » Tue May 15, 2018 7:29 pm

DH had zofran and steroids as pre-meds in his IV, and zofran and compezine pills to take at home. He never even used the pills.
Caregiver to DH, dx @ 50, mets to liver/lungs/lymphs, MSS, quad wild
9/16 CEA 114, partial blockage, left hemi, perm. colostomy
11/16 port in, FOLFOX + Avastin
4/17 CEA 11
6/17 CEA 15, 5FU + A only due to neuropathy
11/17 CEA 38, CAPOX + A
1/18 CAPOX caused hi bilirubin/bad hfs, back to FOLFOX + A
5/18 growth/ascites; change to Vectibex + 66% Irinotecan dose
9/18 CEA 31, shrinkage/no ascites

User avatar
CRguy
Posts: 9591
Joined: Sun Feb 10, 2008 6:00 pm

Re: Sustol Injection Pain

Postby CRguy » Tue May 15, 2018 11:14 pm

The injection issue may be from :
a poor location ?
poor technique ?
reaction to the actual active medication or any of its components ?
... any or all of which, could produce an injection site granuloma
not unheard of and sometimes it just "happens" !

As for the actual medication, it is one of a common class used for anti-nausea, especially for chemo patients.
MANY homies here will have encountered or been offered at least one of these along with other options !

WIKI has a good synopsis here
and the trade names of the major ones available are as follows :

Ondansetron = brand name Zofran
Dolasetron = brand name Anzemet
Palonosetron = brand name Aloxi
Granisetron = brand name Kytril
BUTT ...... " An extended release injectable version of granisetron, known as Sustol is also available in the United States as of 2016 "

While I do not recall anyone else mentioning Sustol specifically .... the mechanism of action of "depot" injections or long acting / slow release preparations is to form a small reservoir in the tissues from which the medication will be released over time.
A depot injection is a slow-release, slow-acting form of your medication. It isn't a different drug – it's the same medication as the tablet or liquid form, but it's administered by injection, and it is given in a carrier liquid that releases it slowly so it lasts a lot longer.

HOW they do that ...IS the devil in the details, and likely the source of your concerns.

Hope things resolve comfortably and quickly ..... BUTT

If you are having any issue with any med or treatment ... tell your docs !!!
and keep bugging them until they give you an answer or a solution which works FOR YOU !!

Cheers on the journey
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far


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