Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

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Koreysue
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Joined: Mon Apr 30, 2018 2:36 pm

Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby Koreysue » Fri May 11, 2018 2:57 pm

I’m coming up on my 1 year anniversary of diagnosis. (Stage 3, CC 2 nodes positive) I have always struggled with anxiety- specifically about getting cancer, (Oh the irony). Now that I’ve had cancer, and finished treatment, I’m becoming crippled with fear of recurrence. I have strange twinges of pain in my right rib area, off and on, sometimes the left side too. It does seem to be after eating mostly, but not always. My cea was tested a few weeks ago and was considered normal at 2.4, liver labs normal. All the while, I’m having this pain. On one hand I think- maybe I’m being paranoid and am too tuned in to every little twinge, but then I think- what if I wait to get checked out and regret it. I have a scan and colonoscopy scheduled for the end of July, debating wether to go in sooner.
I’m wondering how many people on here have had gallbladder issues following treatment. I’m hoping it’s that, and not a recurrence.

Ron50
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Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby Ron50 » Fri May 11, 2018 6:09 pm

I know of several people who had gallbladder issues following crc and subsequent chemo. I was a few years past chemo (5fu and levamisole) I went to ER with severe upper abdominal pain. I had a diseased gall bladder and a small gallstone had blocked off my pancreatic duct. I had my gall bladder removed. IT was full of sludge and around 150 small black cholesterol stones. I asked my doctor about the tie between cancer , chemo and gall. He said that he has found that cancer and chemo don't cause problems like gallbladder . He thinks that they are pre existing problems but chemo promotes earlier onset. That is just his opinion. I have often lamented the lack of on going research into long term survivors. I am 20 years out from my cancer treatment but at no time have I ever been approached by any researcher to see why I am still alive and what long term effects I have from treatment. I would ask your doc to check your gallbladder, it is usually done with a simple ultrasound, Ron.
dx 1/98
st 3 c 6 nodes
48 sessions 5Fu/levamisole
no recurrence cea <.5
numerous l/t side effects of chemo

rockhound
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Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby rockhound » Fri May 11, 2018 9:08 pm

Koreysue wrote:I’m coming up on my 1 year anniversary of diagnosis. (Stage 3, CC 2 nodes positive) I have always struggled with anxiety- specifically about getting cancer, (Oh the irony). Now that I’ve had cancer, and finished treatment, I’m becoming crippled with fear of recurrence. I have strange twinges of pain in my right rib area, off and on, sometimes the left side too. It does seem to be after eating mostly, but not always. My cea was tested a few weeks ago and was considered normal at 2.4, liver labs normal. All the while, I’m having this pain. On one hand I think- maybe I’m being paranoid and am too tuned in to every little twinge, but then I think- what if I wait to get checked out and regret it. I have a scan and colonoscopy scheduled for the end of July, debating wether to go in sooner.
I’m wondering how many people on here have had gallbladder issues following treatment. I’m hoping it’s that, and not a recurrence.


I had my gallbladder out years before my RC diagnosis. Gallbladder attack pain was unlike anything I'd ever felt and honestly, more acute/painful than anything I went through during my cancer-related surgeries - as Ron50 stated, severe upper abdominal pain. The first attack came out of nowhere right after eating a really fatty, cheese-rich meal. Thought it was a heart attack but hen realized about 10 minutes later that I was still breathing fine and alive, so must be something else. Gallstones are to diagnosis via ultrasound..
42 yr old male
Diagnosed December 2016, age 41
Stage 1/IIA rectal cancer - T2/3N0M0 via MRI (MRI indicates stage 1; onc/surgeon = stage 2a)
Lynch syndrome, MSH6 mutation, MSI
2 to 3/2017 Xeloda + Radiation
5/10/17 - Robotic LAR with temp. loop illeostomy, 0/20 lymph nodes
6 to 7/2017 - Six cycles Folfox @ full strength
9/20/17 - Ileostomy takedown
10/17 - CT, NED
1/18 - 5mm polyp removed during colonoscopy
5/18 - CT, NED

Koreysue
Posts: 2
Joined: Mon Apr 30, 2018 2:36 pm

Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby Koreysue » Fri May 11, 2018 10:04 pm

Thank you both for your reply. I should probably schedule an appointment for an ultrasound.
Ron- I agree more research is needed. Great news to hear about your long survival.
Take care,
Korey

weisssoccermom
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Location: Pacific NW

Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby weisssoccermom » Fri May 11, 2018 11:42 pm

FYI....not all gallbladder problems are caused by gallstones and therefore don't show up on an ultrasound. I had my gallbladder out in 1996 after many episodes of upper right sided pain. Numerous ultrasounds didn't reveal any gall stones but the doctors still suspected gallbladder issues (especially since gallbladder problems also ran in my family....mom/dad/brother/aunt and the list goes on). I ended up having a HIDA scan which led to a conclusive diagnosis of severe sludgy bile. I may not have had gallstones, but the effect was still the same. I will say, as others have said, that the pain is SEVERE...not just twinges. Certainly not saying that your 'twinges' couldn't be related but everyone that I know of that has had gallbladder problems have severe, bending over, take your breath away pain.

That being said, I DO have weird twinges in the area of my gallbladder....sometimes they seem like painful muscle spasms....almost like a charley-horse kind of a cramp...and have had these for years. Numerous ultrasounds and even an MRI of the region showed nothing and the docs all agree that it is likely just scar tissue/adhesions... these likely from my gallbladder surgery. I am one of those whose body seems to host scar tissue very well.....after all my surgeries ( over a dozen now...mostly orthopedic), I have had nothing but trouble with adhesions. They are pesky little things that you really can do little about. This isn't necessarily very likely, but a hiatal hernia can also cause some of the same symptoms you are describing....particularly after a meal.
Dx 6/22/2006 IIA rectal cancer
6 wks rad/Xeloda -finished 9/06
1st attempt transanal excision 11/06
11/17/06 XELOX 1 cycle
5 months Xeloda only Dec '06 - April '07
10+ blood clots, 1 DVT 1/07
transanal excision 4/20/07 path-NO CANCER CELLS!
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mhf1986
Posts: 112
Joined: Sat Mar 11, 2017 8:30 pm
Location: near DC

Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby mhf1986 » Sun May 13, 2018 1:46 pm

I"m thinking DH has similar issue...CT scan last week showed gallstones and bilirubin is up to 6.5. He's not jaundiced looking. We meet with the oncologist on Tuesday and I am going to request an ultrasound. I wonder if there is something blocking the flow from the liver like a gallbladder full of stones.

M
Caregiver to DH, dx age 50, mets to liver/lungs, MSS, quad wild
10/16: descending hemicolectomy w/perm. colostomy, CEA 114
11/16: port in, FOLFOX + Avastin; CEA down to 11 by 4/17
6/17: CEA 15, OX discontinued for now due to neuropathy
11/17: CEA 38, changed to CAPOX+A; CEA down to 29 in 12/17
1/18: scan stable, CAPOX caused bilirubin of 4.5/bad hfs, back to FOLFOX+A
5/18: scan shows growth of liver tumors/lung nodes; 6.4 bilirubin too high for irinitican, started Vectibex

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dianetavegia
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Re: Newbie here: gallbladder or recurrence? Anyone know if gallbladder issues are common after folofox?

Postby dianetavegia » Mon May 14, 2018 1:29 pm

I had emergency gall bladder surgery during FOLFOX! I'd never had symptoms prior to that either. My gall bladder pain was in my right side/ back. I thought it was muscle cramps but one night I went to the ER twice for the pain (All my children were natural childbirth and I have a high tolerance for pain). They did an ultrasound and found a number of stones. Surgery was done within 2 hours and I was sent home right after I woke up.

Diane
Stage IIIB cc surgery 1/7/09. 5/17 nodes. 12 tx FOLFOX
Stage IVa 2/15/12. CEA 6.4 PET = 1.5cm liver met. HR 4/11/12 No chemo

Nine years 3 months since my original dx and Six years post liver resection.
NED April 2018!
“O Lord my God, I cried out to You, And You healed me.”
Psalms 30:2


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