Teri's TIL trial at NCI

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teri3
Posts: 386
Joined: Fri Jan 09, 2015 11:03 am

Teri's TIL trial at NCI

Postby teri3 » Tue May 08, 2018 6:47 pm

Hey gang! I had VATS today at NCI to harvest TIL cells. The surgery went very well. They took my chest tube out at 3:30 :) I've been up and walking around feeling pretty good .....as the nurse said its probably the drugs LOL.
Friday I scheduled for apheresis, I'll let you know how that goes.
Now starts the waiting game to see if they can get anything to grow...wish me luck :) I'll try to keep you all updated.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

Geoman
Posts: 19
Joined: Sun Apr 29, 2018 8:48 pm

Re: Teri's TIL trial at NCI

Postby Geoman » Tue May 08, 2018 6:54 pm

Prayers for you. I hope you set a new standard.
Dx @ 44, rectal cancer-stage 4 with Mets to liver 8/16
CEA 19
Kras g12d; Braf
Ypt3,ypN1a,ypM1
5 rounds 5fu with avastin (4) 9/16-11/16
PVE/Liver Resection 12/16
28 days rad/xeloda 2/17-3/17
APR-4/17
Clear Margins
7 rounds 5Fu with avastin- 5/17-8/17
CEA-1.2
NED-12/17, 1/18,
Multiple spots in lungs-5/18

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Shana
Posts: 399
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: Teri's TIL trial at NCI

Postby Shana » Tue May 08, 2018 11:11 pm

Wishing you all the luck and good fortune in the world!

Shana
DX - 12/16
MSS - KRAS wild
Well-differentiated adenocarcinoma at splenic flexure
Stage IV CC with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17
CEA 12/17 - 38.7! 1/18 - 33! 2/18-36.5 3/18-39.8 4/18- 54 (ugh) 5/11/18 -78 :( 5/25/18-63!!!!
CT-Scan 5/18 -mixed -some progression and some shrinkage, possibly pseudo
Irinotecan increased to 200mg on 5/7/18 in response to increased CEA and it's working as of 5/25!

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DH2Sleen
Posts: 80
Joined: Thu Jan 29, 2015 10:10 am

Re: Teri's TIL trial at NCI

Postby DH2Sleen » Wed May 09, 2018 5:31 am

This is terrific news Teri. Grow cells grow. I hope they are highly reactive cells that wipe out all of the cancer cells. GO Lymphocytes!
DW, Sleen dx 9/2013 @47yo: IIIc T4b N2b MX
09/2013 colectomy
10/2013 - 3/2014 FOLFOX
04/2014 - 6/2014 Rad to bladder
12/2014 +'ve for lung mets, MX becomes M1
03/2015 enter TIL trial @ NIH
07/01/15 Receive 148E9 cells to target K-ras G12D mutation
08/11/15 Reduction=18%, no new tumors
09/15/15 25%
10/20/15 27%; PET -> one hot met
11/24/15 30% all mets shrinking
01/26/16 46% but one suspicious met
03/24/16 46% but one growing
04/07/16 Lung lobectomy NED for the first time

NHMike
Posts: 1697
Joined: Fri Jul 21, 2017 3:43 am

Re: Teri's TIL trial at NCI

Postby NHMike » Wed May 09, 2018 6:47 am

Great stuff. The stuff that they learn from you and others in this is going to make treatment easier for those to come.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

sdino
Posts: 62
Joined: Tue Mar 28, 2017 5:32 pm

Re: Teri's TIL trial at NCI

Postby sdino » Wed May 09, 2018 6:48 am

Great news !
Caregiver for Wife 52 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-1.5cm
MSS, KRAS-mut G12D; TP53
Folfox/Avastin + Oxi 11/16 to 5/17, 8/17 Start Xeloda + Avastin
CT Scans: 5/17 colon & lung met shrinkage,11/17 and 1/18 slight progression lungs/colon; 5/18, 7/18 stable lungs/colon
NCI YOUNGER TIL Trial NCT03412877 - 1/18 VATs lung surgery 2 mets wedge resect
CEA: 16 - 11/16; 0.6 - 5/17; 3.0 - 11/17; 4.4 - 1/18; 5.7 - 2/18; 4.9 - 3/18, 4.0 - 5/18, 7/18 - 6.8, 9/18 - 5.1

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Robino1
Posts: 462
Joined: Fri Aug 11, 2017 12:09 pm
Facebook Username: Robin.lawthers
Location: Florida

Re: Teri's TIL trial at NCI

Postby Robino1 » Wed May 09, 2018 10:06 am

Wishing you amazing success!


Your success will be ours in the future!
At 54 2014 1st colonoscopy colon cancer detect
Colon resect margins clear. No chemo Stage II
2017
Distend abd, pain in intestines.
CT scan seeding & Ascites
Lap diag - cancer on the omentum
CEA 217; 219
FOLFOX started 6/17
CEA 202
8/29/17 CT melting of tumor.
Latest CT scan shows 2 new tumors and return of ascites.
CEA: (2017)9/30 -109; 10/12 -99.1; 11/4 -90.7; 11/30 -70.7; 12/14 -83.4; (2018)1/4 -73.3; 2/1-84.2; 89.2; 89.8; 88.5; 81.8: 93.5; 107; 119
BRAF V600e

mhf1986
Posts: 141
Joined: Sat Mar 11, 2017 8:30 pm
Location: near DC

Re: Teri's TIL trial at NCI

Postby mhf1986 » Wed May 09, 2018 5:53 pm

Thank you for doing this! I will wave at you tomorrow as I drive by NIH every day to get to my office. I say prayers each time I go past the staff entrance that the doctors are successful there.
Caregiver to DH, dx @ 50, mets to liver/lungs/lymphs, MSS, quad wild
9/16 CEA 114, partial blockage, left hemi, perm. colostomy
11/16 port in, FOLFOX + Avastin
4/17 CEA 11
6/17 CEA 15, 5FU + A only due to neuropathy
11/17 CEA 38, CAPOX + A
1/18 CAPOX caused hi bilirubin/bad hfs, back to FOLFOX + A
5/18 growth/ascites; change to Vectibex + 66% Irinotecan dose
9/18 CEA 31, shrinkage/no ascites

teri3
Posts: 386
Joined: Fri Jan 09, 2015 11:03 am

Re: Teri's TIL trial at NCI

Postby teri3 » Wed May 09, 2018 9:28 pm

Mhf1986 I'll wave back :). Thanks everyone for the encouragement. It helps.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

teri3
Posts: 386
Joined: Fri Jan 09, 2015 11:03 am

Re: Teri's TIL trial at NCI

Postby teri3 » Wed May 09, 2018 9:37 pm

I've felt pretty good today post surgery. I hit a bit of a hick up last night I had to wear a monitor because of sleep apnea and my bloodox kept going below 85. But they put me on oxygen and I've been good but a little tired today. Apheresis Friday. Anyone else have apheresis? They say I can go home afterwards but it's a 9 hour drive. Does it make you tired or anything? Maybe drive 4 hours Friday then the rest Saturday? Any suggestions.
Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?
CT growth
VATS l lung 4 10 17
VATS r lung 4 24 17
CT 2 nodules r up and l low :(

Geoman
Posts: 19
Joined: Sun Apr 29, 2018 8:48 pm

Re: Teri's TIL trial at NCI

Postby Geoman » Mon May 14, 2018 8:33 am

Teri

Just wanted you to know we are thInking about you. I pray for success. It means so much to all of us. Kick butt!!! And keep us posted.

Mitch
Dx @ 44, rectal cancer-stage 4 with Mets to liver 8/16
CEA 19
Kras g12d; Braf
Ypt3,ypN1a,ypM1
5 rounds 5fu with avastin (4) 9/16-11/16
PVE/Liver Resection 12/16
28 days rad/xeloda 2/17-3/17
APR-4/17
Clear Margins
7 rounds 5Fu with avastin- 5/17-8/17
CEA-1.2
NED-12/17, 1/18,
Multiple spots in lungs-5/18


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