"Kaplan-Meier Karate" - understanding survival data

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"Kaplan-Meier Karate" - understanding survival data

Postby risto » Sun Apr 22, 2018 6:56 pm

Article by Darrel Francis, MD, April 03, 2018
"Event curves -- we've all seen them, but what do they really mean? What can you glean from their shape and their wiggliness?"

I found this very informative. Anyone researching information on prognosis or clinical trials should understand what these charts mean.
DW Dx 7/15, 41 yo, st IV, 3+ liver mets: 11.3 cm, 7cm, 3cm. MSS.
KRAS, APC, SMAD4, TP53 mut.
7/15-10/15: FOLFOX+bev. x8
11/15-12/15: SIRT (Y90)
1/16: Toxic Hepatitis, chemo break
4/16: Liver resec. fail
5/16-7/16: FOLFIRI x6
8/16: Liver resec.
8/16-11/16: FOLFIRI x6
2/17: IMRT/Xeloda x25
4/17: LAR
6/17: CT: Progression. Peri, Lung, Liver mets. FOLFIRI x6
9/17: FOLFIRI+Bev x5.
11/17: CT: Stable. 5FU+bev. maintenance x5
1/18-2/18: Surgery for SBO
5/18: ascites, acute liver injury

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Re: "Kaplan-Meier Karate" - understanding survival data

Postby CRguy » Sun Apr 22, 2018 10:43 pm

Respectfully :

Kaplan-Meier is a non-parametric stat discussion referable only within its OWN frame of reference.
This discussion has LESS than nothing to do with karate ( please read my bio. )
The quotes about "grasshopper" would refer to Kung Fu the old TV series based on Shaolin Kung Fu tradition ... NOT karate.
Darrel Francis, MD, is a cardiologist ... he should stick to cardiology ... BUTT would never be mine.

Like many putative, media savvy scientists, this person has tried to frame a legit discussion in a topical and colloquial manner.
He has failed ... he should stick to cardiology.

Understanding the meaning of statistical analysis is important.
I would argue this article's author does not meet that objective... JMO


Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Re: "Kaplan-Meier Karate" - understanding survival data

Postby JJH » Mon Apr 23, 2018 3:24 am

JJH wrote:A classic article on the topic of statistics and cancer is the one entitled, "The Median Isn't the Message" by Stephen Jay Gould: https://people.umass.edu/biep540w/pdf/Stephen%20Jay%20Gould.pdf. This article is worth reading in order to understand why we should not pay too much attention to survival statistics,


If anyone is interested in other articles on survival statistics, they can start with this basic overview on Stephen Gould's website:


But if you are looking for a more technical discussion of K-M curves within the specific context of oncology, you can go to some of the articles published more recently in the scientific literature, for example this one published in 2016:

An Introduction to Survival Statistics: Kaplan-Meier Analysis

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