Elevated CEA from radiation?

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tigerpaw
Posts: 57
Joined: Sat Jun 20, 2015 1:34 pm
Facebook Username: kristin.lossius
Location: Norway

Elevated CEA from radiation?

Postby tigerpaw » Thu Apr 12, 2018 8:52 am

I finished radiation to my chest (mediastinal lymph nodes) one month ago. My CEA has risen from 8 before treatment to 18. I had a quite painful esophagitis during and after treatment which may have influenced my CEA. Anyone else experienced this?
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes

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HopeForJesse
Posts: 239
Joined: Wed Feb 24, 2016 9:39 am
Location: Philadelphia

Re: Elevated CEA from radiation?

Postby HopeForJesse » Sun Apr 15, 2018 4:37 pm

Sorry I don’t have input here as we are just going for radiation consult this week. But, I will ask the onc on that when we go.
Curious what the duration of your radiation was in terms of # of cycles? Thanks and best wishes!
DH DX 01/16 49 YO inop RC stage IV liver mets
MSS, mod dif adenocarcinoma, high grade dysplasia, TP53 APC,BRCA2
12/15 CEA 241, FOLFOX to 11/16
LAR/ileo 5/16 Clear margins 1/29 nodes
HAI, reversal, liver resections7/16
FUDR 8/16 -NED 3 mos
Rising CEA 3/17 Xeloda, 5/17 -12/17 Erbitux & Iri stable but lung/lymph mets CEA 2.7
4/18 CEA 87 :( 5/18 5 days SBRT radiation to sternum CEA declining again 6/13/18 21.1
Ephesians 3:20 Our God is able to do immeasurably more than we can ask or imagine!

tigerpaw
Posts: 57
Joined: Sat Jun 20, 2015 1:34 pm
Facebook Username: kristin.lossius
Location: Norway

Re: Elevated CEA from radiation?

Postby tigerpaw » Mon Apr 16, 2018 8:57 am

I had 13x 3 Gy sessions of radiation to mediastinum.
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes

Foggyocean
Posts: 15
Joined: Wed Aug 30, 2017 12:31 pm

Re: Elevated CEA from radiation?

Postby Foggyocean » Tue Apr 17, 2018 8:12 am

My husband had radiation (SBRT) to his liver met in January. His CEA went from 4.8 pre-radiation to 14.3 about 3 weeks after his last dose. Two weeks after that (5 weeks after his last dose) it was back down to 3.2 and has continued to fall since. His radiation oncologist told us this could happen so we were expecting it...still made me nervous though!
45 year old caregiver to Husband
DX 3/16: 3cm Adenocarcinoma of sigmoid colon, Grade 2
4/16: colon resection; Stage IIIc (at diagnosis), 6/42 nodes, CEA: 11, MSS, KRAS
5/16: Baseline CT & MRI show 4 liver mets, CEA: 99
5/16-1/17: 4x FOLFOX, liver resect, 8x FOLFOX
8/17: 1 liver met, CEA 46.5
10/17: HAI pump; FUDR + Folfiri Oct-Apr '18 w/Dr. K @MSK
1/18: SBRT to liver met; CURRENTLY NED CEA 0.8

tigerpaw
Posts: 57
Joined: Sat Jun 20, 2015 1:34 pm
Facebook Username: kristin.lossius
Location: Norway

Re: Elevated CEA from radiation?

Postby tigerpaw » Tue Apr 17, 2018 1:01 pm

Thank you. Hopefully my CEA rise is caused by radiation, too
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes

User avatar
HopeForJesse
Posts: 239
Joined: Wed Feb 24, 2016 9:39 am
Location: Philadelphia

Re: Elevated CEA from radiation?

Postby HopeForJesse » Tue Apr 17, 2018 1:13 pm

We are at the consult and our radiation oncologist also confirmed expectation of rising CEA post treatment then falling again.
DH DX 01/16 49 YO inop RC stage IV liver mets
MSS, mod dif adenocarcinoma, high grade dysplasia, TP53 APC,BRCA2
12/15 CEA 241, FOLFOX to 11/16
LAR/ileo 5/16 Clear margins 1/29 nodes
HAI, reversal, liver resections7/16
FUDR 8/16 -NED 3 mos
Rising CEA 3/17 Xeloda, 5/17 -12/17 Erbitux & Iri stable but lung/lymph mets CEA 2.7
4/18 CEA 87 :( 5/18 5 days SBRT radiation to sternum CEA declining again 6/13/18 21.1
Ephesians 3:20 Our God is able to do immeasurably more than we can ask or imagine!

tigerpaw
Posts: 57
Joined: Sat Jun 20, 2015 1:34 pm
Facebook Username: kristin.lossius
Location: Norway

Re: Elevated CEA from radiation?

Postby tigerpaw » Tue Apr 17, 2018 3:57 pm

Very good news. I will have my CEA tested next week. Hopefully it will be on its way down.
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes


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