New TIL Trial NIH/NCI NCT03412877

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sdino
Posts: 81
Joined: Tue Mar 28, 2017 5:32 pm

New TIL Trial NIH/NCI NCT03412877

Postby sdino » Mon Apr 09, 2018 1:10 pm

New TIL trial at NCI/NIH with Dr. Rosenberg as lead investigator opened this month. https://clinicaltrials.gov/ct2/show/NCT03412877
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-4.0cm
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/2016 to 2/2019
iTCR TIL Trial NCT03412877 4/19 to 7/19 Off trial, - Sept. 2019 TIL trial NCT01174121
CT Scans: 1/2020 lung met shrinkage 36%, Liver & Brain met shrinkage 90%
CEA:16-11/16; 5.1-9/18; 63.6-8/19; 1.2.9-1/20

SarahS
Posts: 49
Joined: Sat Mar 11, 2017 12:44 pm

Re: New TIL Trial NIH/NCI NCT03412877

Postby SarahS » Mon Apr 09, 2018 7:05 pm

Thanks for posting about this sdino

Can anyone explain how this differs from the trial that Sleen had success on?
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras G12C MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

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DH2Sleen
Posts: 81
Joined: Thu Jan 29, 2015 10:10 am

Re: New TIL Trial NIH/NCI NCT03412877

Postby DH2Sleen » Tue Apr 10, 2018 6:16 am

SarahS wrote:Thanks for posting about this sdino

Can anyone explain how this differs from the trial that Sleen had success on?

Sleen’s trial used the actual, cloned cells from her tumor to infuse back into her body to go after the tumors. In this new trial, the cells from a tumor are removed and tested for reactivity. The genetic code of cells that are reactive to the mutations in the tumor are “transcribed” into a virus. The virus becomes a messenger of the gene that recognizes the mutation. They call the virus a transcription vector because it carries the genetic code of the T-cell receptor (TCR) from the Tumor Infiltrating Lymphocyte (TCR) to other, younger lymphocytes that they get from the patient’s blood through apheresis. So, once transcribed, these young lymphocytes have learned to look for the cells that have the mutation that caused the patient’s tumors. The doctors think that they can double the efficacy of the process because these “young” lymphocytes can live longer and are more active. But it is at a cost of time. The process takes longer because of the added step of reprogramming the young lymphocytes, so the patients need to be able to survive on other treatments until the new, personalized treatment can be prepared. I think it adds a couple of months to the process that already takes three months; so a patient could expect five months total between tumor harvest surgery and treatment with the new cells.
Last edited by DH2Sleen on Tue Apr 10, 2018 5:53 pm, edited 1 time in total.
DW, Sleen dx 9/2013 @47yo: IIIc T4b N2b MX
9/2013 colectomy
10/2013 - 3/2014 FOLFOX
4/2014 - 6/2014 Rad to bladder
12/2014 +'ve for lung mets, MX becomes M1
3/2015 enter TIL trial @ NIH
7/1/15 Receive 148E9 cells to target K-ras G12D mutation
8/11/15 Reduction=18%, no new tumors
9/15/15 25%
10/20/15 27%; PET -> one hot met
11/24/15 30% all mets shrinking
1/26/16 46% but one suspicious met
3/24/16 46% but one growing
4/7/16 Lung lobectomy NED for the first time
3/3/20 Still NED "cured"

sdino
Posts: 81
Joined: Tue Mar 28, 2017 5:32 pm

Re: New TIL Trial NIH/NCI NCT03412877

Postby sdino » Tue Apr 10, 2018 7:04 am

Thanks DH2, Great explanation. and yes, it does take longer to develop these Young TILs, so NCI reviews your disease progress very closely to ensure they do not put you at risk.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-4.0cm
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/2016 to 2/2019
iTCR TIL Trial NCT03412877 4/19 to 7/19 Off trial, - Sept. 2019 TIL trial NCT01174121
CT Scans: 1/2020 lung met shrinkage 36%, Liver & Brain met shrinkage 90%
CEA:16-11/16; 5.1-9/18; 63.6-8/19; 1.2.9-1/20

SarahS
Posts: 49
Joined: Sat Mar 11, 2017 12:44 pm

Re: New TIL Trial NIH/NCI NCT03412877

Postby SarahS » Tue Apr 10, 2018 12:23 pm

Thank you DH2Sleen for that comprehensive explanation. This is one to watch for sure
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras G12C MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12


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