The Colon Club

Is anybody taking Tagmet ( cemitadine ) and modified citrus pectin prior and after surgery to avoid surgery induced metastasis???

Yes we did and it all worked great, but we added a lot more stuff. The MCP was hard to stir cleanly and we often only used 5 grams per day instead of 15 grams. To anybody who uses cimetidine, I would suggest getting at least one CA199 blood test, preferably with ESR (inflammation), hSCRP (inflammation), HgbA1C (sugar), LDH and TSH (thyroid) before the surgery for comparison and best use. In retrospect we could have used even more vitamin D3, and did so on the next surgery.

CA199 is one of two companion markers to best target cimetidine (the other, CSLEX1, a particular CD15s antibody marker is really hard to get done, Tissue CA199 does 90% of the "work"). Your surgeon or oncologist will almost certainly be ignorant and misinformed about their history and literature for CRC; all of ours were simply out of the loop. Seems like there is not much oncological advertising and entertainment budget for a 10 cent pill....

To anybody who uses cimetidine, I would suggest getting at least one CA199 blood test, preferably with ESR (inflammation), hSCRP (inflammation), HgbA1C (sugar), LDH and TSH (thyroid) before the surgery for comparison and best use. In retrospect we could have used even more vitamin D3, and did so on the next surgery.

Hey RP1954,

Would you mind sharing more details of this? I'm currently taking Cimetidine (which my onc doesn't really buy...) and I will need to convince him the reason of doing the CA199 blood test (let alone all the other ones...). Appreciate it!

When did you start taking cimetidine ?

The first CA199 test, best before chemo or radiation or surgery, can be used to improve a guess whether cimetidine should help interfere with your cancer cells' metastasis and immune defeating processes or not. A CRC patient whose cancer tissues are high in both CA199 and CSLEX1 markers is a very high risk patient, likely due to high HIF-1a, or HIF-2a content/activity, and likely having (some or many) KRAS mutant or BRAF mutant cells.

If the CA199 test is less than 2, at any time, the Japanese intepretation was that cimetidine biologically, categorically couldn't help long term 5FU treatment, about 8-10% of CRC patients.

As the unstimulated test values increase, the likelihood of CA199 values reflecting bad cancer processes rises. Thyroid problems, inflammation, excess sugarm chemo, radiation can stimulate CA199 blood values, hence the extra panels. If various extra panels are steady then CA199 readings are likely directly comparable, like CEA. Some less drastic diseases or other cancer may increase CA199. The Japanese results suggest that cimetidine for CA199 helps other cancer somewhat too.

If there is a really serious question about cimetidine utility, then stain the pathology samples for CA199 and CSLEX1. The Japanese research published in the 2000s shows them to be far better companion markers for cimetidine than any tests he has for Erbitux.

Western research is simply studying these selectin (t)issues to death (guess whose...), presumably for new expensive answers. 2017, 2018 papers

In competent hands, Matsumoto (2002) and the subsequent Japanese papers are like a Rosetta stone. If I recall correctly, Life Extension Foundation started sounding the clarion about cimetidine in the 1980s, sialyl Lewis epitopes (selectins) in the late 1990s, and then recommending Imclone (long merged away) for the staining DIY.

Eleda wrote:Is anybody taking Tagmet ( cemitadine ) and modified citrus pectin prior and after surgery to avoid surgery induced metastasis???

I used both. So far, so good.

Thanks for the replies, im going to see if the doc will do my ca199- ,but if not I think I'll still go ahead and tKe it prior to surgery next month, I'm already taking other supplements, so eont fo any harm
Thanks
ADELE