Blocked colon perforation, what chemo to choose?

[monicafcp]

Hi all,

My father has just been dx'ed Stage IV colon cancer (details on signature).

We are looking into 1st line treatments, but doctors have diverging opinions:

one says "take FOLFOX, as FOLFIRI gives you increased toxicity due to anatomical alteration of intestinal tract" (I wonder: could this in any way affect the blocked perforation??)

the other says "take FOLFIRI, as FOLFOX can give you permanent neuropathy fuelled by pre-diabetes" (Is this a real thing? - he doesn't even have any pre-diabetes induced neuropathy now)

If the blocked perforation opens, he has to have emergency surgery and risks sepsis.

Anyone has some info to share on this?

Thank you in advance,

[Shana]

Hi Monica,

Welcome and sorry that your father's diagnosis brought you here. I don't know enough to comment about one treatment over another. Every patient is different and responds differently to chemo cocktails.

I have never heard of a blocked colon perforation. I thought all perforations had to be repaired and treated vigorously with antibiotics to prevent sepsis.

I hope some other members with far more knowledge will have answers to your questions.

Wishing your father and you the very best as you battle this disease

Shana