SweetC80 wrote:This was always the hardest part for me, the unknown what does every little test mean. My mom's CEA would fluctuate up and down a little and when there was no real change, but the times there were growth or spreading we saw large jumps in her numbers. Everybody is different in how much CEA is even a marker for them. Does your mom have any scans coming up? My mom's onco always reinforced that CEA was a guide not a diagnostic tool and only imagining could really show him what was going on. I hope her lung mets are still stable.
rp1954 wrote:Given the economics, frequent longevity, and improved QOL, I would look into ADAPT style protocols for mCRC - capecitabine (or UFT-LV) + celecoxib; with the easy adjuncts like PSK, EGCG, quercetin and curcumin. There are lots of others that can be additive and that we have used with a low total cost for a high quality of life result.
Theoretically IV vitamin C should reduce the VEGF-A consumption of Avastin for RAS mutant CRC that often expresses serum CA199 over 19 before surgery/chemo/rad tx, and LDH over 200. Similarly on CA199 and LDH, cimetidine may improve problems associated with mutants, but by different mechanisms. When I say "theoretically", my mCRC wife has never had to use Avastin but we do use a lot of other adjuncts too.
Your mum's CEA series is concerning as series with a nadir but still immature for statistics and pattern matching. If it is any solace, the doubling time is slower than many mCRC cases. There will be some information in the rest of your mom's bloodwork and more is possible with expanded panels.
Mercy110 wrote:...suspect the combination of drugs in HK is a bit different compare to US, but we will see how it goes.
Apart from the advice, do you find my mum's CEA is worrying even though it is growing slowly? Do the word "Nadir" imply chemo for life or met?
rp1954 wrote:Mercy110 wrote:...suspect the combination of drugs in HK is a bit different compare to US, but we will see how it goes.
Some drug regimens are pretty standard, the different combinations are what you choose instead of merely accept. You also have the tegafur drug, TS-1, and maybe UFT (tegafur uracil) that aren't available in the US. We chose UFT-LV over Xeloda for a personalized treatment with mild drugs and nutraceuticals, reasonable cost, better result, better quality of life.Apart from the advice, do you find my mum's CEA is worrying even though it is growing slowly? Do the word "Nadir" imply chemo for life or met?
Nadir is the low point in the curve, and hypothetically could occur with an operable met too. Concerned, we react on nutraceuticals about that level of change to shift immune, chemo treatment back into a more responsive range.
Stage IV inoperable implies chemo for life; the question is which chemo.
There are papers that show better results with milder combinations. These treatments are considered experimental, developmental and/or nonstandard. They are so mild and were so promising, we chose a "virtual trials" route for unique combinations that can be done at home (take more pills). You even have the advantage of presumably reading and writing chinese for shopping the mainland for wider choices and lower prices.