I had anaphylactic reaction to the Oxi, but not during my second round, I had it on my 7th round, it was very bad, my BP was at 33 and I could not breathe and my neutrophil was at all time low (it was low before, but after the allergic reaction, it dropped big time).
But since I am Stage IV, my doctor wanted me to try my best to take it. I had two Onc and one wanted me to try, the other one didn't want me to risk. I finally decided to take the risks. So I took steroids the day before the infusion, right before the infusion and the day following the infusion and some medication to help increase neutrophil. And during the infusion, they made it drip really slow, normally Oxi would take only an hour or two to finish, I took 5 hours to finish. With all these help, I managed to take all 13 rounds of FOLFOX without any reduction.
From my 7th - 10th round, I still had some allergies, like minor rash and itchiness, but it was manageable (instead of a big patch of rash all over my body, I had like small red dots in some places). The reaction really died down from 10th - 13th round, I don't know how it got better, but every infusion I received after the 10th, there was less rash. And by the 13th round, there was nothing.
I agree with Lee, try to get a second opinion. To be honest, my legs were like noodle and my whole body was literally shaking in fear when I took Oxi again after my reaction, but if I am given a chance to choose again, I would have done the same.
If I were you, I would throw everything at it, and I would want my team of doctors to fight it with me taking every manageable risk I have got, however scary they may look as long as it's worth it.
F/38 - Dx 8 Mar 17, CEA 80.5
Stage IV Sigmoid Colon, 6 Liver mets, T3N0M1a, KRAS NRAS Wild, G2=Moderately differentiated
3/17- 6/17 - 6 rounds of FOLFOX + Erbitux - CEA 2.5
7/17- 8/17 - 2-stage Liver Resection/Colon/Gall, all clear margin
8/25 - CEA 0.7
9/11 - Started Adjuvant chemo Xelox
9/15 - Intense reaction to Xeloda, it was dropped
9/22 - Folfox resumed, severe allergic reaction to Oxi
11/17 - Clear MRI
12/17 - completed a total of 13 rounds of FOLFOX
1/18 - Clear PET SCAN
3/18 - Clear MRI