We had an experience with para-aortic lymph nodes early on, which are often associated with CA199 as a tissue marker related to KRAS mutants etc. Often CA199 serum marker can be a useful series in the teens and above for advanced CRC, not just "37 and above", the typical Upper Limit (detection cutoff for a single test of pancreatic cancer). For us, a 4 CEA point rise paralleled one 2 cm LN met.
We applied a lot of high potency supplements (onc snickers or barfs here, we don't care) with 5FU, cimetidine (CA199 related) and IV vitamin C. By slightly increasing daily oral 5FU, we could stop and reverse the rising CA199, but not reverse CEA. We then had a single LN cluster cut out, after diligent medical search for an able and willing surgeon, head of dept regional center. Later, we were able to reverse small CEA, CA199, or AFP features with all the oral 5FU, IVC, high potency supplements, cimetidine and celebrex. Some (groups of) supplements clearly made various differences.
Our interim strategy was to stop the LN mets' spread and slow the existing ones down by revitalizing 5FU with ordinary materials, personalized. Sometimes we dissolve or petrify lung or liver features too. Some people have done this with Xeloda and celebrex for over 10 years, it takes personalized chemistry to stop/slow the particular cancer situation. The more active chemistries, the merrier. We had to be more biochemically aggressive than any of the ND/MDs. We steer with expanded blood markers, CBC+CMP+CEA would not quite make it.
watchful, active caregiver for stage IVb CC since early 2010. immuno"Chemo forever," for mCRC