CEA increasing rapidly

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Joined: Wed Jun 08, 2011 3:49 pm

CEA increasing rapidly

Postby emzee » Sun Feb 25, 2018 12:00 pm

Hi, haven't posted in a while. Just wanted to check with others to see if they have had similar situations. My CEA (always an incredibly reliable indicator for me) is increasing dramatically. Have had recent CT and PET. Both show multiple small nodules (we are presuming mets) in both lungs as well as assorted PALNs and a clavicular node. The thought is that there is multiple met sites so expressing more CEA than just a single solid tumor. I have my doubts. I'm MSS and KRAS mutant. Awaiting Foundation One report (onc dropped the ball on that, should have been done a while ago). I'm on weekly 5FU maint.chemo and CEA is continuing to rise. On average of 4 points per week. I have a difficult time with any chemo AND the CEA keeps rising. I think we are missing something somewhere. Has anyone experienced anything similar? Would appreciate any insights.
Dx Nov'10 Stage III rectal CA
Dec'10-11 F5U & 25 rad Txs
Mar'11 res,temp ostomy,pos nodes
Mar'11-Nov '11 FOLFOX 12 Txs
Feb'12 CEA elev;liver tum,Stage IV
Mar'12 Liver res, gallbladder out,ostomy rev
Feb'14 Elev CEA Pos para-aortic lymph nodes
May '14-Aug'14 FOLFIRI + Avastin (6 rnds, red. dose)
Sept-Oct '14 SBRT nodes
Sept'15 CEA elev,new PALN pos
Oct-Nov '15 SBRT nodes
Feb '16 CEA elev,new PALN pos
Apr-May Red dose Stivarga
Oct '16 CEA elev,new PALN pos
'18 mult sm lung mets, PALNs; CEA UP, maint. 5FU

Posts: 5762
Joined: Sun Apr 16, 2006 4:09 pm

Re: CEA increasing rapidly

Postby Lee » Sun Feb 25, 2018 2:47 pm

Since it seem like the chemo is not working very well for you, have you looked into Immunotherapies? Keytruda has been approved for colon cancer.

If you have not already done so, get 2nd opinions at major cancer treatment centers.

Good luck,

rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

Posts: 1398
Joined: Mon Jun 13, 2011 1:13 am

Re: CEA increasing rapidly

Postby rp1954 » Sun Feb 25, 2018 5:58 pm

We had an experience with para-aortic lymph nodes early on, which are often associated with CA199 as a tissue marker related to KRAS mutants etc. Often CA199 serum marker can be a useful series in the teens and above for advanced CRC, not just "37 and above", the typical Upper Limit (detection cutoff for a single test of pancreatic cancer). For us, a 4 CEA point rise paralleled one 2 cm LN met.

We applied a lot of high potency supplements (onc snickers or barfs here, we don't care) with 5FU, cimetidine (CA199 related) and IV vitamin C. By slightly increasing daily oral 5FU, we could stop and reverse the rising CA199, but not reverse CEA. We then had a single LN cluster cut out, after diligent medical search for an able and willing surgeon, head of dept regional center. Later, we were able to reverse small CEA, CA199, or AFP features with all the oral 5FU, IVC, high potency supplements, cimetidine and celebrex. Some (groups of) supplements clearly made various differences.

Our interim strategy was to stop the LN mets' spread and slow the existing ones down by revitalizing 5FU with ordinary materials, personalized. Sometimes we dissolve or petrify lung or liver features too. Some people have done this with Xeloda and celebrex for over 10 years, it takes personalized chemistry to stop/slow the particular cancer situation. The more active chemistries, the merrier. We had to be more biochemically aggressive than any of the ND/MDs. We steer with expanded blood markers, CBC+CMP+CEA would not quite make it.
watchful, active researcher and caregiver for stage IVb/c CC since early 2010. 2 surgeries; 8 yrs immuno-Chemo for mCRC, now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher

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Joined: Sun Feb 25, 2018 8:27 pm

Re: CEA increasing rapidly

Postby brentling » Sun Feb 25, 2018 8:39 pm

I was told that my maintenance (5fu) would end when my cea jumped 50% - from around 4 -5 to 6 -7. It jumped a month ago, along with small growth in tumour in liver. So I switched to FolFox, I did 16 orunds of Folfiri last year and was on a kind of break.

Sounds like the maintenance mode is over for a bit.

Oncologist said that after 12 rounds of Folfox I would probably go straight to maintenance with minimal breaks (I will be travelling off chemo)

Good luck!

Posts: 154
Joined: Sun Oct 08, 2017 3:25 am

Re: CEA increasing rapidly

Postby henry123 » Sun Feb 25, 2018 11:22 pm

My cea went crazy from around 2 to almost 30, 000 within 7- 8 months.
It was collaborated by pet/ ct scans showing rapid growth of mets in lung , peritoneal region and livers. Oncologist had never seen such aggressive growth of cea.
No chemo was working . Then it was revealed that I am Lynch with msi-high.

It seems for some msi-high cases 5 fu actually aggravates the situation. ( my opinion )

Immunotherapy in form of Opdivo ( nivolumab ) seems to have worked in my case.

Hopefully, this info helps you.
46yo M
5/16 lap AR 14/21 L nodes +ve
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
msi-h Lynch
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver.
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
2/18 2.3
4/18 2.0
Aspirin start
6/18 1.5 CT clear
8/18 1.3
10/18 1.2
12/18 1.1 CT Clear NED
Vegan yoga juicing apricot
Still on opdivo

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