Rectal Cancer, Folfox, and side effects

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MassMike
Posts: 17
Joined: Sun Nov 19, 2017 11:04 am

Rectal Cancer, Folfox, and side effects

Postby MassMike » Tue Feb 20, 2018 12:24 pm

My mom is on the mop up FOLFOX regimen for her rectal cancer and she just completed her 3rd cycle out of 8 (woohoo!) and she has begun to get a raspy voice. Is this a normal side effect? She has lung nodules that they deemed non suspicious and they're just keeping an eye on them but its freaking me out that this could be signs of lung mets. Her voice is raspy and she clears her throat more often than normal. Is this a normal side effect of FOLFOX?
Mom DX Stage 2/3 Rectal Cancer 8/17
Chemoradiation 9/17-11/17
Surgery w/Temp Colostomy 12/12/17
yP Stage T2N0 0/20 nodes
8 cycles folfox begun 1/15/18
Folfox finished 5/18
Reversal 8/18

cbsmith
Posts: 87
Joined: Sat Nov 28, 2015 11:45 am
Location: New Brunswick, Canada

Re: Rectal Cancer, Folfox, and side effects

Postby cbsmith » Tue Feb 20, 2018 1:11 pm

I found that my voice got a bit hoarse and raspy for a few days after my folfox treatments but would return to normal about a week after treatment. I think it is a normal thing and wouldn’t be related to any lung Mets.
06/14-DX with FAP as 36yo Male
07/14-total colectomy, rectum removal, permanent ileostomy
08/14-DX Stage IIIC, KRAS mutant, MSS
09/14-04/15 - 12 rounds of FOLFOX
07/15-CT showed para-aortic lymph node, onc thght inflammation
10/15-DX Stage IV, CT lymph node tripled in size, 1 small lung met
11/15-FOLFIRI + Avastin
06/16-lymph node is stable, now have a 2nd lung met
01/16-lymph node is stable, lung mets grown 2mm. Still on FOLFIRI + Avastin
11/17 - no chemo since. Lung growth minimal, lymph node is stable

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal Cancer, Folfox, and side effects

Postby NHMike » Tue Feb 20, 2018 1:39 pm

My wife has commented on my voice for a few days after infusion.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

heiders33
Posts: 363
Joined: Sat Nov 04, 2017 11:08 am

Re: Rectal Cancer, Folfox, and side effects

Postby heiders33 » Tue Feb 20, 2018 2:29 pm

My voice got really raspy right after Oxi, and I continue to get a dry throat after talking too much. I’m on my last day of Xeloda and it’s still an issue. I’ve been using a lot of cough drops. This is definitely a side effect - don’t worry about lung mets.
40 year-old female
May 2017: Dx rectal cancer T3N2M0
MSS, KRAS G12D
6/17: 28 days chemorad
9/17: LAR/loop ileostomy, CAPOX six rounds
3/18: reversal
9/18: liver met, resection/HAI pump, 11 rounds 5FU, 1 round FUDR
11/19 - local recurrence, brachytherapy, 3 weeks targeted radiation
12/21 - end colostomy


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