Rectal Cancer, Folfox, and side effects

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MassMike
Posts: 16
Joined: Sun Nov 19, 2017 11:04 am

Rectal Cancer, Folfox, and side effects

Postby MassMike » Tue Feb 20, 2018 12:24 pm

My mom is on the mop up FOLFOX regimen for her rectal cancer and she just completed her 3rd cycle out of 8 (woohoo!) and she has begun to get a raspy voice. Is this a normal side effect? She has lung nodules that they deemed non suspicious and they're just keeping an eye on them but its freaking me out that this could be signs of lung mets. Her voice is raspy and she clears her throat more often than normal. Is this a normal side effect of FOLFOX?
Mom DX Stage 2/3 Rectal Cancer 8/17
Chemoradiation 9/17-11/17
Surgery w/Temp Colostomy 12/12/17
yP Stage T2N0 0/20 nodes
8 cycles folfox begun 1/15/18
Folfox finished 5/18
Reversal 8/18

cbsmith
Posts: 75
Joined: Sat Nov 28, 2015 11:45 am
Location: New Brunswick, Canada

Re: Rectal Cancer, Folfox, and side effects

Postby cbsmith » Tue Feb 20, 2018 1:11 pm

I found that my voice got a bit hoarse and raspy for a few days after my folfox treatments but would return to normal about a week after treatment. I think it is a normal thing and wouldn’t be related to any lung Mets.
06/14-DX with FAP as 36yo Male
07/14-total colectomy, rectum removal, permanent ileostomy
08/14-DX Stage IIIC colon cancer KRAS mutant, MSS
09/14-12 rounds of FOLFOX
04/15-ended FOLFOX
07/15-CT showed one para-aortic lymph node, onc thought inflammation and said wait 3 mths
10/15-DX Stage IV, CT showed lymph node tripled in size and 1 small lung met
11/15-FOLFIRI + Avastin
06/16-lymph node is stable, now have a 2nd lung met
01/16-lymph node is stable, lung mets grown 2mm. Still on FOLFIRI + Avastin

NHMike
Posts: 1847
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal Cancer, Folfox, and side effects

Postby NHMike » Tue Feb 20, 2018 1:39 pm

My wife has commented on my voice for a few days after infusion.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

heiders33
Posts: 314
Joined: Sat Nov 04, 2017 11:08 am

Re: Rectal Cancer, Folfox, and side effects

Postby heiders33 » Tue Feb 20, 2018 2:29 pm

My voice got really raspy right after Oxi, and I continue to get a dry throat after talking too much. I’m on my last day of Xeloda and it’s still an issue. I’ve been using a lot of cough drops. This is definitely a side effect - don’t worry about lung mets.
36 year-old female
May 2017: Dx rectal cancer at T3N2M0
MSS, KRAS G12A
June-July 2017: 28 days of XEL/radiation
Sep 2017: laparoscopic LAR/loop ileostomy
Oct 2017 - February 2018: XELOX six rounds
Mar 2018: reversal
Apr 2018: CEA 2.1, normal blood counts
May 2018: CT liver spot
Aug 2018: Abnormal PET, CEA 2.4
Sep 2018: robotic and laparoscopic liver resection with HAI pump
Oct 2018: Clear CT and colonoscopy, CEA 1.7, begin six months FUDR and FOLFIRI


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