Side effects question

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Joined: Fri Nov 03, 2017 9:20 pm

Side effects question

Postby ilovemyfrenchie » Mon Feb 19, 2018 11:04 am

Good morning!

I have a question. My mom gets Folfiri + avastin every 2 weeks and has gotten 8 treatments so far. Since starting Chemo she has little side effects with the typical disconnect days side effects of diarrhea and fatigue for 3 days, no nausea. But now she’s been having nausea/vomiting on chemo day and then the rest of the week. My question is does the side effects get worse as the treatments go on? I asked the oncologist and she said it shouldn’t and that it should stay the same throughout the chemo treatments. Her CEA numbers has been decreasing each time and her colostomy bag output has been the same. Appetite good, when she’s not feeling nausea.

Just curious.
Daughter to 59 yo w/ Stage 4 Mets to liver & peritoneal
10/1/17 ER trip for GI bleed found rectal tumor (CEA 71)
10/2/17 emergency colostomy (no resection, told tumor inoperable due to Mets found)
10/17 started Folfiri with Avastin (CEA 171)
8/18 CT = liver Mets continue to shrink (CEA 4)

“Chemo for life” hoping for surgery soon

Posts: 87
Joined: Sat Nov 28, 2015 11:45 am
Location: New Brunswick, Canada

Re: Side effects question

Postby cbsmith » Mon Feb 19, 2018 12:18 pm

I found my side effects built up and got worse as they went along. After having folfiri + avastin treatments for about a year the nausea got worse and I was sick a few times. They continued to build over the next year, although we were able to manage them a bit with new medicine, before we stopped folfiri and switched to a different plan.
06/14-DX with FAP as 36yo Male
07/14-total colectomy, rectum removal, permanent ileostomy
08/14-DX Stage IIIC, KRAS mutant, MSS
09/14-04/15 - 12 rounds of FOLFOX
07/15-CT showed para-aortic lymph node, onc thght inflammation
10/15-DX Stage IV, CT lymph node tripled in size, 1 small lung met
11/15-FOLFIRI + Avastin
06/16-lymph node is stable, now have a 2nd lung met
01/16-lymph node is stable, lung mets grown 2mm. Still on FOLFIRI + Avastin
11/17 - no chemo since. Lung growth minimal, lymph node is stable

Posts: 1907
Joined: Fri Jul 21, 2017 3:43 am

Re: Side effects question

Postby NHMike » Mon Feb 19, 2018 6:12 pm

I think that they are somewhat cumulative. With Oxaliplatin, they are definitely cumulative.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

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