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Beloved fiancée
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Postby Beloved fiancée » Wed Feb 14, 2018 1:07 pm

Hello warriers
My beloved fiancé had to reduce his oxaliplatin from 191.25 mg to 152 mg due to extremely fatigue. I would like to hear if any of you had to drop the dosage. What is the common dosage you all started and then dropped to?

Just worried about the therapy effect!
Last edited by Beloved fiancée on Wed Feb 14, 2018 3:38 pm, edited 1 time in total.
Diagnosed 0ct 2017 colon Cancer
Procedure: right hemicolectomy
Stage: 3BT4 Mucinous with Signet-Ring Cell poorly differentiated. :(
Treatment: Started Jan. 2018 Folfox
Ct scan July 2018: clear with prominent mesenteric 11X9 mm
Pet scab Aug 2018: CLEAR
Now and Forever Cured! Thank to the LORD

Posts: 403
Joined: Fri Mar 31, 2017 7:28 am
Facebook Username: aqx99
Location: Pfafftown, NC

Re: oxaliplatin

Postby Aqx99 » Wed Feb 14, 2018 1:21 pm

I don't know what my actual doses were, but my oxaliplatin dose was reduced twice during treatment due to side effects. My oncologist said that it is still effective, even at the reduced dose.
Anne, 40
Stage IIIB Rectal Cancer
2/21/17 Dx, Age 39
2/21/17 CEA 0.9
3/23/17 - 5/2/17 Chemoradiation, 28 treatments
6/14/17 Robotic LAR w/temp loop ileostomy, ovaries & fallopian tubes removed, 2/21 lymph nodes positive
7/24/17 - 12/18/17 CapeOx, 6 Cycles
7/24/17 Dx w/ovarian cancer
9/6/17 CA 125 11.1
11/27/17 CEA 2.6
12/5/17 CT NED
12/13/17 CEA 2.9
1/11/18 CA 125 8.6
1/23/18 Reversal
3/21/18 CT enlarged thymus
4/6/18 PET NED
7/10/18 CT NED
7/11/18 CEA 2.6
9/18 Bilateral Prophylactic Mastectomy

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Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: oxaliplatin

Postby susie0915 » Wed Feb 14, 2018 1:37 pm

Mine was reduced once due to weight loss. I'm not sure what actual dosage level was. I don't think it's unusual for doctors to drop dosage levels to help curtail side effects. There is a range I think they work with, as I know when my oncologist had to reduce dose of my xeloda for a second time due to diarrhea he mentioned that he didn't want to drop it much more. I'm sure the dosage level is still within therapeutic range.
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoidoscopy/only scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod
7/17 no change lung nod
10/17 Clear pel/abd CT
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, clear CT pel/abd/lung nod no change
11/18 CEA .6

Posts: 146
Joined: Thu Aug 18, 2016 7:31 am

Re: oxaliplatin

Postby zephyr » Wed Feb 14, 2018 1:57 pm

Like others, I don't know the dosages I received but mine was dropped at least once -- maybe twice-- because of peripheral neuropathy.
Nov-2009 Early stage CRC found during routine colonoscopy
2010, 2011, 2014 Follow up colonoscopies, all clear
Jun-2016 CRC found during routine follow up colonoscopy, surgery, Stage 4, KRAS, inoperable lung mets
Aug-2016-May-2018 Folfox, 5FU & Avastin, 5FU, Folfiri & Cyramza
Aug/Sep-2018 YAG laser surgeries (Germany) on both lungs, 11 nodules (9 mets) removed
Oct-2018 ... holding pattern

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Joined: Sat Nov 04, 2017 11:08 am

Re: oxaliplatin

Postby heiders33 » Wed Feb 14, 2018 1:57 pm

I had my last dosage dropped to 50% because of fatigue and some neuropathy. My onc was even open to cancelling it because it was the last one.
36 year-old female
May 2017: Dx rectal cancer T3N2M0
6/17: 28 days chemorad
9/17: LAR/loop ileostomy
10/17 - 2/18: XELOX six rounds
3/18: reversal
5/18: CT liver spot, blood counts normal
8/18: Abnormal PET, CEA 2.4
9/18: liver resection/HAI pump
10/18: Clear CT/sigmoidoscopy
10/18 - 4/19: 6MO FUDR/5FU

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Re: oxaliplatin

Postby horizon » Wed Feb 14, 2018 9:16 pm

My onc immediately reduced the dosage when I told him I was getting some neuropathy in my fingertips. I don't know what my dosage was before/after.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 7 years NED). Is this real life?

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Joined: Fri Sep 01, 2017 1:28 pm

Re: oxaliplatin

Postby SweetC80 » Fri Feb 16, 2018 2:35 pm

I've known 3 people IRL who had oxaliplatin, and while I don't know the actual dosage all three had to have their dose reduced because of either fatigue or severe neuropathy.
My Mom
12/16 Stage IIIb Rectal Ca CEA 1.2
1/17-2/17 Chemoradiation CEA 4.4
5/17 Entire Colon, Rectum & Anus removed Perm Ileostomy Bag
9/17 Stage IVb 9cm Liver Met & 7mm Lung Nodule CEA 197
9/17 FOLFIRI CEA 160
10/17 Confirmed KRAS Pos CEA 210
11/17 Met growths Liver 10cm & Lung 8mm CEA 425
12/17 FOLFOX again Met growths Liver 13cm & Lung 1cm CEA 405
12/17 Xifaxan due to Hepatic Encephalopathy
12/17 New 2cm liver Met
1/18 CEA 992
2/8/18 Passed Peacefully

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Re: oxaliplatin

Postby CRguy » Sat Feb 17, 2018 2:00 am

Beloved fiancée wrote: I would like to hear if any of you had to drop the dosage. What is the common dosage you all started and then dropped to?
Just worried about the therapy effect!

I have found the exact dosages may vary according to specific chemo protocol, patient's health status / comorbidities and different cancer centers' "preferences".

When I started FOLFOX ( June 2010 ) the standard oxaliplatin dosing I received was 85 mg/m² BSA for 9 cycles
and it was reduced to about 65 mg/m² BSA for the next 3 cycles due to significant neuropathy.... = the dirty dozen of FOLFOX for me :evil:
[[ since chemo doses were based on BSA (Body Surface Area) ... it would all depend on your BF's BSA as to the exact doses received,
BUTT it appears to be about a 20% reduction which is in line with what I had. ]]

The therapy effect .... ??????
I am still here 8 years later, after finishing that chemo ... SO ...... :shock:
so far ... so good

Best wishes
CRguy on the journey
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Joined: Fri Jul 21, 2017 3:43 am

Re: oxaliplatin

Postby NHMike » Sat Feb 17, 2018 9:53 am

I had my third round 10 days ago. The dosage is based on weight and I had the dosage reduced to 80%. I still have cold sensitivity ten days later though the warmer temperatures have helped. I still can't drink anything room temperature or colder. I still have fatigue as well though it declines with time.

I was okay after the first infusion and the second hit me like a ton of bricks. I couldn't believe how bad it was and felt like quitting the rest of the treatment. We also waited an extra week between the second and third and it was a BIG help.

My term for Oxiliplatin is "Brutal". It's different for everyone but most people that I've heard from have a tough time with it.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

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Location: Midwest

Re: oxaliplatin

Postby Cj51 » Sat Feb 17, 2018 10:43 am

I also had my dosage reduced due to Neuropathy and then had to stop because I became allergic. 8 years later, I'm still cancer free, so what I did get must've worked.

Best of luck to you,

DX Stage IIIb RC, T3N1M0, April 2010, 51
6 wks Xelox/rad 6/10
resection, temp illeostomy 8/10 Complete response!
12 rounds FOLFOX for clean up 9/10, Allergic to Oxi, started Xeloda only 12/10
Ileo takedown 9/28/11
10/15 NED

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