GrouseMan wrote:My wife was on Avastin for a very long time and the worse side effect she had from it was very slight BP elevation from it and some blood when she blew her nose in the morning. She thought the combination of Erbitux and Avastin where a piece of cake compared to the FOLFOX, and she didn't have all that much trouble with that. My wife's oncologist was a firm believer in the use of Avastin in CRC. Added it right away as soon as he could after her initial resection. I think its gotten a bad rap myself. Initially a lot of people on these forums that was getting it complained of terrible headaches etc and I think that was because the high BP it often induced and that wasn't treated until after the fact if at all. My wife's oncologist started her right away on a low dose of an ACE inhibitor. Her BP was low to begin with so when the avastin made it go up, it wasn't very much with the low does ACE inhibitor. She never had bleeding except briefly in the morning when she went to blow her nose, nor did she ever get the headaches. I haven't heard in quite some time anyone else complaining about avastin on these forums so those that are getting it now I think are being managed correctly on it.
Still good luck with the new treatment program your oncologist is putting you through. Being a former anticancer drug researcher that helped develop one of the first small molecule irreversible EGFr inhibitors I had never read anything about Irrinotecan reversing the resistance to Erbitux and I try and stay as up to date on EGFr inhibitors as I can. I'd be interested in any literature or clinical trial info on that subject.
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