Hello, this is my first post. I hope Im making this sound more like a discussion than a letter. I am student and trying to find a clinical trial for my mother. She was first diagnosed in 2015 with Stage 3 and her disease had metastasized in October 2016. She had done many chemotherapy regimens, radiations, and is currently on her second maintenance therapy; Lonsurf. I constantly research and research to try to find the best solution for her disease. We have decided to consider finding a clinical trial as her CEA is increasing with Lonsurf. Its very hard to find a trial let alone information regarding her genetic mutation. I have read and found a a few immunotherapy trials. One trial included specifically targeting KRAS G12V and growing cells and returning them back to the patient. Does anyone here have KRAS G12V mutation with non MSI-High? If so, I'd love to here your experience with treatments and your prognosis. Again, it has been very hard to find information and I'd love to gain any knowledge. Here I have listed a timeline of her diagnosis and treatment. Any advice, recommendations for articles, anything would be helpful. I am eager to find a cure and have her cured entirely.
Colorectal Surgery & Hestorectomy Aug-15
FOLFOX x7 Chemotherapy Regimen 9/22/15 to 12/15/15
FOLFOX x5 Chemotherapy Regimen 03/15/16 to 05/16
Recurrence in Lung Nov-16
FOLFIRI Regimen & Avastin 12/19/16 to 07/17/17
Xeloda Maintenance Therapy & Avastin 08/14/17 to 10/17
Lonsurf Maintenance Therapy 12/18/17-Present