It will affect the overall survival to sequence two chemo drugs differently

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boswind
Posts: 38
Joined: Fri Apr 11, 2014 12:04 pm

It will affect the overall survival to sequence two chemo drugs differently

Postby boswind » Mon Feb 05, 2018 10:15 am

My Onc. showed me a paper published very recently; it's title is "Sequencing Regorafenib Before Cetuximab Leads to Improved Survival in mCRC". Its result is very interesting.

The paper's main point is that if a patient is treated with Regorafenib first and then with Cetuximab, the overall survival will be improved by about 50%, compared to the conventional way: first Cetuximab and then Regorafenib.

The paper can be found by clicking the following link:
http://www.targetedonc.com/news/sequenc ... al-in-mcrc
01.24.2014 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.2014 Completed 5-week Radia+Xeloda
05.07.2014 Had surgery
02.25.2015 CT showed liver and L4 Spine involvement.
03.2015 - 08.2015, folfox + Avastin
08.2015 - 07.2017, 5FU + leucovorin + Avastin for Maintenance
07.2017 - 01.2018, Folfuri + Avastin
01.25.2018 - present, Centuximab + Irinotecan
70 rounds of chemos received (as of 03.2018)
Current CEA: 5.7
MSS, KRAS wild type, BRAF wild type

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