It will affect the overall survival to sequence two chemo drugs differently

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boswind
Posts: 72
Joined: Fri Apr 11, 2014 12:04 pm

It will affect the overall survival to sequence two chemo drugs differently

Postby boswind » Mon Feb 05, 2018 10:15 am

My Onc. showed me a paper published very recently; it's title is "Sequencing Regorafenib Before Cetuximab Leads to Improved Survival in mCRC". Its result is very interesting.

The paper's main point is that if a patient is treated with Regorafenib first and then with Cetuximab, the overall survival will be improved by about 50%, compared to the conventional way: first Cetuximab and then Regorafenib.

The paper can be found by clicking the following link:
http://www.targetedonc.com/news/sequenc ... al-in-mcrc
01.24.14 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.14 Completed 5-week Radia+Xeloda
05.07.14 Had surgery
02.25.15 CT showed stage 4.
03.15 - 08.15, folfox + Avastin
08.15 - 07.17, 5FU+leucovorin+Avastin
07.17 - 01.18, Folfuri + Avastin
02.18 - 03.19, Centuximab + Irinotecan
03.19 - 05.19, Keytruda
05.19 - 9.19, Folfox+Avastin
10.22.19 - rechallenge Centuximab+Irinotecan
110 rounds of chemos received (as of 12.31.19)
MSS, KRAS wt, BRAF wt

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