Xeloda "withdrawal" symptoms?

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menreeq
Posts: 66
Joined: Fri Jun 30, 2017 10:26 am

Xeloda "withdrawal" symptoms?

Postby menreeq » Sat Feb 03, 2018 1:02 am

Has anyone else experienced itching after completing Xeloda? I'm 10 days after my last dose and my hands and feet have been so itchy. I was wondering if I was allergic to Udderly Smooth cream all of a sudden, but I seem to get the itching even without it. Although the cream seems to exacerbate it. I've just taken an oral antihistamine because it is so bothersome.

Thanks for sharing your experiences!
Stage IIA rectosigmoid CC (T3N0M0)
Dx 6/5/17 @age 41, mom to 5 & 2yo girls
Workup: c-scope, EUS, rectal MRI, CT C/A/P
AdenoCA 5.5cm, WHO Grade 2, 0/22 LN, no distant mets
CEA 1.9 (6/5/17), 0.8 (2/28/18)
No lymphovasc/perineural invasion, clear margins
MSI intact, OncotypeDx RS 7
Lap sig colectomy 6/23/17, no ileo/colostomy
Genetics counseling negative for mutations, 4 VUS
Xeloda monotherapy 8/13/17-1/22/18
PET/CT 3/21/18 NED

Lee
Posts: 5621
Joined: Sun Apr 16, 2006 4:09 pm

Re: Xeloda "withdrawal" symptoms?

Postby Lee » Sat Feb 03, 2018 2:33 am

Not sure where you live. Any chance you are dealing with dry skin. Here in Arizona, dry skin is the norm this time of year, and dry skin is a big part of "itchy" problem. Maybe just one possibility this time of the year to consider :shock:

Bed Bath and beyond "Miracle hand Repair" in my go to.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

Beckster
Posts: 263
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: Xeloda "withdrawal" symptoms?

Postby Beckster » Sat Feb 03, 2018 10:39 am

I finished Xeloda monotherapy is June... yes, dry skin and I still get episodes over 6 months out. Try using Eucerin for sensitive skin.
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Tumor type: Adenocarcinoma
Tumor size: 3.5 cm x 2.5 x 0.7 cm
Tumor grade: G3 (surgical) G2 (pre-op)
TNM: T3N0M0/IIA
lymph nodes: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion-discontinued
1/2/17 to 6/9/17- Xeloda monotherapy
6/26/17, 12/12/17, 6/18/17 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/17-3.1, 6/17-3.0
Clear Colonoscopy 10/17 :D

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mypinkheaven
Posts: 455
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Facebook Username: Sally Cunningham
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Re: Xeloda "withdrawal" symptoms?

Postby mypinkheaven » Sat Feb 03, 2018 12:20 pm

Xeloda can cause "hand & foot" syndrome.

http://chemocare.com/chemotherapy/side- ... drome.aspx
MSS, KRAS Wild NRAS Mutated
9/2012 CRC IIB Lft Colectomy 0 lymph nodes 0 Chemo
10/2013 CT clear
11/15 CEA 2.7 to 4.6
11/15 Spread to uterus. Hysterectomy
2/16 Pelvic radiation 25, brachytherapy 3
4/16 - 6/16 Xeloda
6/16 CT Several lung nodules 5 mm
8/16 CT Nodules still present. Most stable. Some growth
11/16 Transfer to UCSD Moores
12/16 Folfox + Avastin failed
2/17 Folfiri + Erbitux
8/17 5FU+Erbitux No 5FU bolus
7/18 Spread to vagina
6/18 Folfiri + Avastin + Trametinib
6/18 CEA dropping

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horizon
Posts: 1473
Joined: Tue Apr 12, 2011 10:10 pm

Re: Xeloda "withdrawal" symptoms?

Postby horizon » Sat Feb 03, 2018 2:55 pm

mypinkheaven wrote:Xeloda can cause "hand & foot" syndrome.

http://chemocare.com/chemotherapy/side- ... drome.aspx


That's what I was going to say at only ten days out from last taking it. Mine went away so hopefully yours will too!
I'm just a dude who still can't believe he had a resection and went through chemo (currently 7 years NED). Is this real life?

menreeq
Posts: 66
Joined: Fri Jun 30, 2017 10:26 am

Re: Xeloda "withdrawal" symptoms?

Postby menreeq » Sat Feb 03, 2018 3:44 pm

I've had hand foot syndrome since cycle 2. I've been well moisturized with Udderly Smooth. What's weird is the itching started AFTER my last dose and despite the cream. Sometimes the cream seems to make it worse, and I've considered the possibility of a developing allergy to the cream. My HFS symptoms of redness, skin thickening and peeling have all gotten better. I think it is unusual to develop a different symptom related to HFS only at the end, unless it's a cumulative effect I am only experiencing after 8 cycles.

Thanks for the feedback.
Stage IIA rectosigmoid CC (T3N0M0)
Dx 6/5/17 @age 41, mom to 5 & 2yo girls
Workup: c-scope, EUS, rectal MRI, CT C/A/P
AdenoCA 5.5cm, WHO Grade 2, 0/22 LN, no distant mets
CEA 1.9 (6/5/17), 0.8 (2/28/18)
No lymphovasc/perineural invasion, clear margins
MSI intact, OncotypeDx RS 7
Lap sig colectomy 6/23/17, no ileo/colostomy
Genetics counseling negative for mutations, 4 VUS
Xeloda monotherapy 8/13/17-1/22/18
PET/CT 3/21/18 NED

Lee
Posts: 5621
Joined: Sun Apr 16, 2006 4:09 pm

Re: Xeloda "withdrawal" symptoms?

Postby Lee » Sat Feb 03, 2018 4:24 pm

menreeq wrote: . . . What's weird is the itching started AFTER my last dose and despite the cream. Sometimes the cream seems to make it worse, and I've considered the possibility of a developing allergy to the cream. . .
Thanks for the feedback.


You just might be developing an allergy to it. May want to try something different

I did not think of this last night, butt when I get out of the shower I use Cetaphil Moisturizing Cream (vs lotion). Intense moisture for dry, sensitive skin. Fragrance free. I get mine at Costco.

Hope it gets better for you,

Lee
Last edited by Lee on Sat Feb 03, 2018 5:48 pm, edited 1 time in total.
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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susie0915
Posts: 818
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: Xeloda "withdrawal" symptoms?

Postby susie0915 » Sat Feb 03, 2018 5:48 pm

Yes I am constantly moisturizing. It's like with the oxi my neuropathy didn't really start until 2 months after I finished treatments. Weird.
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoid/scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod
7/17 no change lung nod
10/17 Clear pel/abd CT
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, clear CT pel/abd/lung nod no change

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mypinkheaven
Posts: 455
Joined: Fri May 20, 2016 4:29 pm
Facebook Username: Sally Cunningham
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Re: Xeloda "withdrawal" symptoms?

Postby mypinkheaven » Sat Feb 03, 2018 6:02 pm

menreeq wrote:I've had hand foot syndrome since cycle 2. I've been well moisturized with Udderly Smooth.


I've read that a cream with urea helps. Maybe the Udderly Smooth isn't getting to the skin layer underneath the very top - that seems like it could cause itching. Urea helps get rid of that very top super dry layer.
MSS, KRAS Wild NRAS Mutated
9/2012 CRC IIB Lft Colectomy 0 lymph nodes 0 Chemo
10/2013 CT clear
11/15 CEA 2.7 to 4.6
11/15 Spread to uterus. Hysterectomy
2/16 Pelvic radiation 25, brachytherapy 3
4/16 - 6/16 Xeloda
6/16 CT Several lung nodules 5 mm
8/16 CT Nodules still present. Most stable. Some growth
11/16 Transfer to UCSD Moores
12/16 Folfox + Avastin failed
2/17 Folfiri + Erbitux
8/17 5FU+Erbitux No 5FU bolus
7/18 Spread to vagina
6/18 Folfiri + Avastin + Trametinib
6/18 CEA dropping

NHMike
Posts: 1558
Joined: Fri Jul 21, 2017 3:43 am

Re: Xeloda "withdrawal" symptoms?

Postby NHMike » Sat Feb 10, 2018 8:27 am

I did not have skin issues after Neo-Adjuvant with Xeloda but have them with Adjuvant. The cold winter has had an effect on my skin as well. I often wear Nitrile Gloves to prevent moisture loss from all of the washing and to help heal skin cracks. I've also had skin discoloration on the backs of my fingers and little brown splotches on my skin.
6/17: ER rectal bleeding; Colonoscopy
7/17: Stage 3B rectal. T3N1bM0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda +radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8
MSS, KRAS G12D
10/17: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx 8 cycles 12/17-6/18


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