New "Universal" Cancer Vaccine is under development at Stanford University

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boswind
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Joined: Fri Apr 11, 2014 12:04 pm

New "Universal" Cancer Vaccine is under development at Stanford University

Postby boswind » Thu Feb 01, 2018 9:20 am

Stanford University just announced that they are developing a cancer vaccine. A clinical trial with 15 patients will start soon.

We know there is no FDA approved cancer vaccine yet for treatment. The lead researcher Dr Levy states the vaccine contains two components activating the T-cells in the tumors. The mice study shows that if the vaccine is injected into one tumor, not only will the affected tumor shrink and disappear, but also the other tumors of the same type in the different locations will disappear as well.

https://med.stanford.edu/news/all-news/ ... -mice.html
http://www.dailymail.co.uk/health/artic ... ccine.html

We understand in the past many potential cancer vaccines failed all to show effectiveness. We hope this 2nd generation of Cancer Vaccine will succeed. If it does succeed, It will be definitely a true and big break-though.
Last edited by boswind on Thu Feb 01, 2018 9:30 am, edited 1 time in total.
01.24.2014 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.2014 Completed 5-week Radia+Xeloda
05.07.2014 Had surgery to remove 13cm sigmoid-colon and rectum.
02.25.2015 PET/CT/MRI scans show liver mets and L4 Spine involvement.
MSS, KRAS wild type, BRAF wild type
Mar 2015 - Aug 2015, folfox + Avastin
Aug 2015 - Jul 2017, 5FU + leucovorin + Avastin for Maintainance
Jul 2017 - Present, folfuri + Avastin
Current CEA: 5.6
Total over 50 rounds of chemo treatment received

fumaros
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Location: Syracuse, NY
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Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby fumaros » Thu Feb 01, 2018 9:29 am

I was coming here to post on this. It is very exciting. I really hope it works. Having such a treatment would bring hope and change so many lives.
Diagnosed 4/8/16, age 29
Colectomy 4/20/16
Stage III, T4bN1 Tumor 7x6.5x2. Muscinous Adenocarcinoma with SRC features
2/16 lymph nodes
CEA 4/14/16 - 16.8
CEA 6/2/16 - 1.9
CEA 6/17/16 - 0.87, 7/16 - 1.33, 12/16 - 1.14, 4/17 - 0.6, 7/17 - 0.5, 10/17 - 0.9
FOLFOX began 6/24/16 - 11/25/16
10 round FOLFOX, 2 round 5-FU & Leucovorin
MRI & CT 8/16 - NED, CT 12/16 - 10/17 - NED

Eleda
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Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby Eleda » Thu Feb 01, 2018 11:27 am

Was only reading this this morning,
Looks very promising
Any idea when the results will b published or know anyone doing the trial????
Adele
SWF, 47
Mom to 3 sons 6/8/12
Dec4th colo for intermittent rectal bleeding over the Summer
CEA 4.4
DX T3 L3C M0 2.5/3 cm above AV
JAN 3RD started 1650mg Zelda 2xday, concurrent with 28 radiation

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juliej
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Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby juliej » Thu Feb 01, 2018 5:20 pm

Thanks for posting, boswind!

From Dr. Levy's mouth to God's ears! This is a promising development! :D
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 12/13/2017, CEA<1

PeterG
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Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby PeterG » Thu Feb 01, 2018 8:36 pm

Seems so promising! Anyone here have any more information? Nice that their universal group of cancers specifically mentions CRC—-so often not the case.
DX Aug. 2013 Resection 09/13.
08/14 CT : .7 CM pulmonary nodule--further CT: growth & multiple nodules.
03/15 15 dendritic cell vaccine-monthly
05/16 begin 3000 MG Xeloda & Avastin
11-16 shrinkage.”Sstable" CT scan scheduled
2/2017: Port installed. Begin Folfiri and Avastin
8/2017: Xeloda, Avastin and Iranotican. 3-wk cycle.
2-6-18: small pulmonary embolim—some growth in one pulmonary tumor. Start Xarelto.
2-8-18 : Change of chemo: Xeloda with Oxaliplatin no avastin.

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GrouseMan
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Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby GrouseMan » Fri Feb 02, 2018 10:08 am

Here is a link to the paper recently published in Science Translational Medicine:

http://stm.sciencemag.org/content/10/426/eaan4488

The abstract is available to read by the public. Subscription required to read the full Text. This is quite amazing result but be aware its still going to be a while before human trials. This is a study in Mice only right now. It requires the tumor to be injected. This is similar to the effect that is shown by injection of Rose Bengal (in a formulation called PV-10 they have been having success with in Melanoma).

Also have a look at the SD-101 and DV-281 drugs by Dynavax which also work on TLR9:

http://www.dynavax.com/our-pipeline/can ... notherapy/

Lots of interesting ways to pump up the immune system to fight cancer. Coming up with a universal one that can be effective at advanced stages of disease will be the real test!

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

mariane
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Joined: Sun Sep 13, 2015 6:16 pm

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby mariane » Fri Feb 02, 2018 11:28 am

Thank you very much Grouseman! I honestly hoped after I saw the post that you would chime in. I appreciate all your posts and willing to share. Thank you again.
mom of 8 years old twins, dx @ 40 with upper rectal cancer, 10+ liver mets in 6/2015, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

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GrouseMan
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Location: SE Michigan USA

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby GrouseMan » Fri Feb 02, 2018 1:55 pm

Thanks - I pop in from time to time still now after the passing of my wife back in Jun of last year. I don't comment much unless I have something to contribute. Mostly support of Maia and Tom (DK) but now that Tom is gone there seems to be less of that sort of scientific exchange going on, and I don't have as much desire for researching things as I did when motivated by my wife's condition. I've little time to dig very deep now that I am responsible for everything in our household myself. Work, dogs (8), horse, pigeons (18), house yard etc. I broke 5 ribs back the beginning of November in a fall off my wife's horse, (Trying to keep him fit) which slowed me down for a while. It was the weekend of what would have been our 35th anniversary.

Take care and good luck.

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

NHMike
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Joined: Fri Jul 21, 2017 3:43 am

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby NHMike » Sat Feb 03, 2018 5:48 pm

Thanks for the papers - I'll have a look and ask my son to have a look. It's too late for me but it's always good to know about this stuff for recurrences.
6/23/17: ER rectal bleeding; Colonoscopy
7/13: Stage 3B rectal. T3N1bM0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/30: LAR, Temp Ileostomy, Path Complete Response
12/20: Started CapeOx

Lee
Posts: 5455
Joined: Sun Apr 16, 2006 4:09 pm

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby Lee » Sat Feb 03, 2018 10:59 pm

GrouseMan wrote:Thanks - I pop in from time to time still now after the passing of my wife back in Jun of last year. I don't comment much unless I have something to contribute. Mostly support of Maia and Tom (DK) but now that Tom is gone there seems to be less of that sort of scientific exchange going on, and I don't have as much desire for researching things as I did when motivated by my wife's condition. I've little time to dig very deep now that I am responsible for everything in our household myself. Work, dogs (8), horse, pigeons (18), house yard etc. I broke 5 ribs back the beginning of November in a fall off my wife's horse, (Trying to keep him fit) which slowed me down for a while. It was the weekend of what would have been our 35th anniversary.

Take care and good luck.

GrouseMan



(((GrouseMan)))

Thinking of you. 5 ribs, so sorry, that must have been awful "painful". Hope you are doing tons better.

Yes we lost a few good people this past year, your wife, Brownbagger, Tom and BeansMama, just to name a few. I pray for the day, there is a cure for this horrible disease.

Take care of yourself,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

mariane
Posts: 590
Joined: Sun Sep 13, 2015 6:16 pm

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby mariane » Mon Feb 05, 2018 9:13 am

GrouseMan wrote:Thanks - I pop in from time to time still now after the passing of my wife back in Jun of last year. I don't comment much unless I have something to contribute. Mostly support of Maia and Tom (DK) but now that Tom is gone there seems to be less of that sort of scientific exchange going on, and I don't have as much desire for researching things as I did when motivated by my wife's condition. I've little time to dig very deep now that I am responsible for everything in our household myself. Work, dogs (8), horse, pigeons (18), house yard etc. I broke 5 ribs back the beginning of November in a fall off my wife's horse, (Trying to keep him fit) which slowed me down for a while. It was the weekend of what would have been our 35th anniversary.

Take care and good luck.

GrouseMan

You have your hands full. Be careful. You are needed here, especially with Tom gone :( Thank you again for all the info.
mom of 8 years old twins, dx @ 40 with upper rectal cancer, 10+ liver mets in 6/2015, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

User avatar
GrouseMan
Posts: 734
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: New "Universal" Cancer Vaccine is under development at Stanford University

Postby GrouseMan » Fri Feb 09, 2018 2:50 pm

Here is a follow up discussion of this potential Universal vaccine Idea from The Pipeline from another fellow drug discovery chemist you may all be interested in.

http://blogs.sciencemag.org/pipeline/ar ... y-frontier

Enjoy,

GrouseMan.
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017


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