I did your regimen and am still doing the 5FU + Avastin. I dropped the Oxaliplatin after the 10th treatment.
Cold drinks bothered my throat, touching very cold objects was like a burning sensation. First bite was pretty bad for me.
The best thing to do is start a spreadsheet or journal and make a note of your side effects, when they start and when they stop.
Cold throat only lasted a few days for me. Cold hands thing lasted about 5, as well as first bite. These are all caused by the oxaliplatin. The only side effect I have from the 5FU is thrush in my mouth. I use something called Magic Mouthwash. It is prescribed by the oncologist. Thrush like stuff shows up about 2-3 days after I disconnect from the pump. I use the Mouthwash from Monday to Friday. As soon as I start feeling smoothness on the roof of my mouth, I stop using the Mouthwash.
You want to get a prescription for an anti nausea med. you will be getting some in IV during chemo and it lasts about three days. The first time I had chemo, I didn't feel nauseous until the afternoo/evening of pump disconnect. After that first time, I started taking the pill in the afternoon the day of disconnecting from the 5FU pump. I found that I only needed that one pill that one day. Keeping track of all of this helped me find out how long I really needed to be on any extra meds.
I would experiment on stopping something early and see what happened.
Not everyone gets the same side effects. Some get them worse, others have no problem with these. The above are more common and most people get some form of them. Severity really is an individual thing. The most important thing to remember is to tell your doctor about anything that seems unusual to you. If something doesn't seem to be working (for example an anti nausea med) let the doc know. There are other meds that may work better for you.
You can call the nurses at the chemo center any time you have questions or concerns. They are absolutely the best. They will get to your doc to get an answer for you. You don't have to wait for your next scheduled appointment. They are there to help and they really are amazing.
As far as working, I'm retired but I know I'd be able to work through all of this. It hasn't slowed me down at all. Staying active helps with everything.
You Can Do This! The payoff can be huge = life.