49 with Stage IV and mets to peritoneum and abdomen

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Katrinaks24
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Joined: Mon Jan 08, 2018 10:49 am
Facebook Username: Katrina Saacke

49 with Stage IV and mets to peritoneum and abdomen

Postby Katrinaks24 » Mon Jan 08, 2018 11:06 am

Surgeon at USC Keck was not able to complete surgery because the discovery of mets. Treatment plan is folfoxiri with Avastin. Port placement on Wednesday and chemo on the 15th. The goal is to get to the point of being able to have surgery with HIPEC. I see most posts about folfiri and folfox, but not about folfoxiri. Can anyone share their experiences?

WarriorSpouse
Posts: 83
Joined: Tue Aug 16, 2016 9:02 pm

Re: 49 with Stage IV and mets to peritoneum and abdomen

Postby WarriorSpouse » Mon Jan 08, 2018 12:34 pm

Every cancer and patient is different. Use what works for you. Some it is 5FU and others Folfuri.

Listen to your own response to the treatment issued by your oncologist and adjust if and when needed. As long as you are getting the advice from a major cancer center, you will be following the most recent practices, and will be able to be nimble in your changes in treatment when needed.

It looks like you are being treated in NYC at Sloan Kettering, so that is a great place to start!
All the best for 2018, and your journey forward.
WS
Spouse of wife 47 years old
10/2014, Stage IV Metastatic CC
Lymph node involvement 12/15, w/ positive PET on para-aortic lymph nodes.
5 cm sigmoid tumor resection as well as positive Virchow lymph node.
KRAS mut, Highly Differentiated, Lynch Negative
Folfox and Avastin 1 YR (Oxi for 5 months) NED 05/2015
Zeloda and Avastin since 01/2016
Chemo break 03/2017, back on Zeloda and Avastin 04/2017.

"...Perseverance is not a long race; it is many short races one after the other."
-Walter Elliot

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O Stoma Mia
Posts: 976
Joined: Sat Jun 22, 2013 6:29 am

Re: 49 with Stage IV and mets to peritoneum and abdomen

Postby O Stoma Mia » Mon Jan 08, 2018 3:27 pm

Katrinaks24 wrote:... I see most posts about folfiri and folfox, but not about folfoxiri. Can anyone share their experiences?

    FOLFOXIRI: Irinotecan 165 mg/m 2 over 60 minutes then oxaliplatin 85 mg/m 2 plus leuovorin 200 mg/m 2 concurrently over 120 minutes then 5-FU 3200 mg/m 2 over 48 hours; repeat every 2 wk for four to six cycles.

    Reference:
    Falcone A, Masi G, Brunetti I, et al. The Triplet Combination of Irinotecan, Oxaliplatin and 5FU/LV (FOLFOXIRI) vs the Doublet of Irinotecan and 5FU/LV (FOLFIRI) as First-Line Treatment of Metastatic Colorectal Cancer (MCRC): Results of a Randomized Phase III Trial by the Gruppo Oncologico Nord Ovest (G.O.N.O.). Proceedings from the 42nd Annual Meeting of the American Society of Clinical Oncology. Atlanta, Ga. June 2006. Abstract # 3513:

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ppanamared
Posts: 4
Joined: Wed Jun 28, 2017 5:47 pm

Re: 49 with Stage IV and mets to peritoneum and abdomen

Postby ppanamared » Mon Jan 08, 2018 5:07 pm

For me the two didn't do anything without the Irinotecan..once they added that in all the bloating and pain disappeared in almost instantly a few days after...hopefully the two work well for you tho.

rachel2017
Posts: 32
Joined: Tue Oct 17, 2017 9:17 pm

Re: 49 with Stage IV and mets to peritoneum and abdomen

Postby rachel2017 » Mon Jan 08, 2018 8:27 pm

Katrinaks24 wrote:Surgeon at USC Keck was not able to complete surgery because the discovery of mets. Treatment plan is folfoxiri with Avastin. Port placement on Wednesday and chemo on the 15th. The goal is to get to the point of being able to have surgery with HIPEC. I see most posts about folfiri and folfox, but not about folfoxiri. Can anyone share their experiences?


My mom had localized perio met. She was planned to be operate and HIPEC after 8 round of FOLFOX. However, the met spread crazy during the first round of chemo. Currently, she is getting the FOLFOX and Avastin. Most people when they have perio met the chemo don't work very well. If we could choose again. We definitely would choose folfixri or FOLFOX at the beginning. Wish you wiil have a good lucky!
DM 63. 11/16 colonoscopy (high dysplasia)
1/17 laparoscopic,6.5X4X3cm. low adenocarcinoma; 14/14 lym-; MSS. CEA 2;CT-. No chemo.
6/17 abdo pain. CEA 52. CT paracolic nodule 1.4X1.9cm
6/17 CT guided biopsy. Mucinous adenocarcinoma consistent primary tumor.
7/17 pet CT. Ascending colon 1.4X1.1cm SUV 2.4; midline scar 0.9cm SUV3.1
KRAS Gly12Asp
8/16/-9/26/17 Folfox 4 times
10/6/17 CT numorous seedings in abodominal/plvis area. close ascending 7cm; close midline scar 5.7cm.
10/16-12/15/17 Folfox/avastin


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