Keytruda for stage 4 colorectal cancer with low mutation ma1-L

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Maddie01#
Posts: 1
Joined: Fri Dec 22, 2017 2:16 am

Keytruda for stage 4 colorectal cancer with low mutation ma1-L

Postby Maddie01# » Fri Dec 22, 2017 2:49 am

My wife has stage 4 colorectal cancer and has started using Keytruda with chemo tablet
Her readings are low mutation ms1-L
Has anyone had success and how do you know it’s working besides a scan only done 3 sessions
Darryl

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GrouseMan
Posts: 836
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Keytruda for stage 4 colorectal cancer with low mutation ma1-L

Postby GrouseMan » Fri Dec 22, 2017 3:47 pm

Depends whats the Chemo Tablet? That could be anything. Generally speaking MSI Low typed solid tumors haven't responded well to Keytruda. People with MSI-High typically do respond when in combination with FOLFOX or other chemo treatments. There are some studies taking place using Keytruda with other chemo drugs however that it is hoped will turn cold (MSI-Low) tumors to hot (MSI-High) type character, and make them respond better to attack by the immune system.

So if your wife is in a trial with a new combination of Keytruda with some other chemo drug, it would be of interest knowing what that chemo tablet actually is. There are a lot of new combinations being tried right now out there though few seem to be offered to folks with MSI-LOW form of colon cancer. Let us know a little bit more if you can about what exactly the drugs in use are, and someone might be better able to respond to you if they are undergoing the same or similar treatment. I believe there are a couple members that are trying Keytruda but with MSI-High tumors.

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

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henry123
Posts: 209
Joined: Sun Oct 08, 2017 3:25 am

Re: Keytruda for stage 4 colorectal cancer with low mutation ma1-L

Postby henry123 » Mon Jan 22, 2018 11:34 am

Maddie01# wrote:My wife has stage 4 colorectal cancer and has started using Keytruda with chemo tablet
Her readings are low mutation ms1-L
Has anyone had success and how do you know it’s working besides a scan only done 3 sessions
Darryl

Best wishes.
My oncologist monitored it after 3 months ( 6 cycles ) .
I think it takes 3 weeks to 13 weeks for immunotherapy to start showing results.
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
4/18 2
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
6/19 .9 CT clear
1/20 NED Opdivo stop

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WriterGirl1969
Posts: 513
Joined: Sat Mar 05, 2016 3:48 pm
Location: Central NY

Re: Keytruda for stage 4 colorectal cancer with low mutation ma1-L

Postby WriterGirl1969 » Mon Jan 22, 2018 11:34 pm

Maddie01# wrote:My wife has stage 4 colorectal cancer and has started using Keytruda with chemo tablet
Her readings are low mutation ms1-L
Has anyone had success and how do you know it’s working besides a scan only done 3 sessions
Darryl


Our dear friend Beansmama (whose posts you can find here if you search on her name) was stage 4. I can't tell you for sure what her mutation was, but she was Lynch positive and stage 4. They started her on Keytruda in 1/2017 after none of her other treatments worked. Over the next several months her CEA continued to go down and her tumors to shrink. She was doing this in prep for a risky surgery, but the treatments were doing so well they wanted to keep them going. By October of 2017 the doctors were incredibly pleased with her progress. She had surgery in November 2017 to remove the tumor, which was found to be completely dead.

I'll say this so that you aren't caught off guard if you go searching. Beansmama recently passed away, but it was from complications with blood clots and nothing to do with the cancer. She was NED after surgery. So the Keytruda was very positive in her story.

Hope this helps.
Tracy
DX 3/4/2016 Colon Cancer; age 46 Mom of then 4-yr-old
Stage IIIB: T3N1M0
3/31/16 Surgery
4 to 10/2016: Xeloda Monotherapy
CEA: 10/16 0.56, 1/17 0.54
CT CLEAR: 3/6/17; 4/17/18; 4/16/19
NED 3 years
“If I can help somebody as I walk along, then my living shall not be in vain.”


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