Hi. I'm putting this post out here even if it takes a long time for people to reply.
Does anyone have advice on how to manage the gastrointestinal side effects of Mekinist/trametinib (a MEK inhibitor like cobimetinib)? I am armed with loperamide and cheap products that can be purchased from a drug store. I would like to learn how to reduce the number of diarrhea episodes that I have, and the GI symptoms (like "semi-burning poo-poo intestinal feeling" and "I want to poop but it won't happen"-feeling), and the chest tightness which I assume is GERD. I wonder if loperamide can work prophylactically, or if some antacids reduce symptoms.
Feb. 2015 at age 39: Dx stage IIIb cecal cancer extending into appendix
March 2015 at age 40: Began FOLFOX, discontinuing early after 10 cycles due to suicidal ideation and difficulty moving
Oct. 2016 at age 41: Dx stage IV with 3 metastases to lungs (one 3.7 cm x 2.2 cm) and 1 to liver