Hi. I'm putting this post out here even if it takes a long time for people to reply.
Does anyone have advice on how to manage the gastrointestinal side effects of Mekinist/trametinib (a MEK inhibitor like cobimetinib)? I am armed with loperamide and cheap products that can be purchased from a drug store. I would like to learn how to reduce the number of diarrhea episodes that I have, and the GI symptoms (like "semi-burning poo-poo intestinal feeling" and "I want to poop but it won't happen"-feeling), and the chest tightness which I assume is GERD. I wonder if loperamide can work prophylactically, or if some antacids reduce symptoms.