Treatment options

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Liana
Posts: 1
Joined: Thu Nov 30, 2017 9:29 pm
Facebook Username: Liana Spiegel

Treatment options

Postby Liana » Thu Nov 30, 2017 11:24 pm

Hi all, I just joined the forum to help my mom. I'm so glad I found this forum! My mom was recently diagnosed with colon cancer, T3N1M0. She had a surgery with clear margins, and she's recovering well. First oncologist suggesting Folfox for 6 months as a mop up treatment (I don't know the dosage yet). I already read some nasty comments about Oxaliplatin, and it made me very nervous. I am pushing for 2nd opinion as far as treatment options (dosage, length, and other types). What questions should we be asking? What is out there besides Folfox? Besides chemo? What else should we know?

Thank you all so much for keeping this forum alive!
For my mom - Dx 63, 10/17
T3N1M0
moderately differentiated
a 5mm spot in a lung (watching)

hawkowl
Posts: 132
Joined: Sun Dec 14, 2014 5:29 am
Location: MN/FL

Re: Treatment options

Postby hawkowl » Fri Dec 01, 2017 12:59 am

I am someone who ended up with significant oxaliplatin toxicity (disabling neuropathy with dysautonomia). BUT I also had a complete pathological response (I received my oxaliplatin before surgery...neoadjuvant FOLFOX). And more than 2 1/2 years later i am still NED. Not an easy decision, but I have no regrets...and if I had to do it all over again, I would choose the exact same protocol.

But I definitely recommend getting a second opinion!!
Dx 12/2014 T3N2MX (distant LPLN) low rectal
12/2014-4/2015: FOLFOX (8 cycles)
4/2015-6/2015: 28 cycles of chemoradiation with xeloda, SBRT
8/2015: Robotic APR with iliac node dissection; path showed ypT0,ypN0 (complete pathological response).
11/2015 scans clear, CEA 2.1
11/2015 parastomal hernia repair
3/2016 CEA 1.7, scans stable...
6/2020 5 years of normal CEA and stable scans
Now dealing with pyoderma gangrenosum.
Totally disabled due to oxaliplatin induced neuropathy and dysautonomia

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O Stoma Mia
Posts: 1709
Joined: Sat Jun 22, 2013 6:29 am
Location: On vacation. Off-line for now.

Re: Treatment options - FOLFOX

Postby O Stoma Mia » Fri Dec 01, 2017 3:57 am

Liana wrote:Hi all, I just joined the forum to help my mom. I'm so glad I found this forum! My mom was recently diagnosed with colon cancer, T3N1M0. She had a surgery with clear margins, and she's recovering well. First oncologist suggesting Folfox for 6 months as a mop up treatment (I don't know the dosage yet). I already read some nasty comments about Oxaliplatin, and it made me very nervous. I am pushing for 2nd opinion as far as treatment options (dosage, length, and other types). What questions should we be asking? What is out there besides Folfox? Besides chemo? What else should we know?

Thank you all so much for keeping this forum alive!


Here is some information on FOLFOX -- FOLFOX is one of the standard first-line chemotherapy regimens for Stage III, but there are other first-line regimens available.

Side effects management under FOLFOX
http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=44542&p=321388#p321388

Here is some information on questions to ask your oncologist:

Questions to ask your oncologist
http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=50520&p=388015#p388015
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Last edited by O Stoma Mia on Sat Dec 02, 2017 4:06 am, edited 1 time in total.

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Treatment options

Postby NHMike » Fri Dec 01, 2017 8:13 am

I met with my oncologist yesterday afternoon and he recommended Folfox or Capox (oral version). So I'm getting the Oxaliplatin. As Stoma Mia said, it's the standard treatment. From what I've read, you need to communicate side-effects with your oncologist so that adjustments can be made, whether that's dropping the Oxaliplatin, decreasing the dosage, taking longer breaks, etc.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

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susie0915
Posts: 945
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: Treatment options

Postby susie0915 » Fri Dec 01, 2017 9:02 am

NHMike wrote:I met with my oncologist yesterday afternoon and he recommended Folfox or Capox (oral version). So I'm getting the Oxaliplatin. As Stoma Mia said, it's the standard treatment. From what I've read, you need to communicate side-effects with your oncologist so that adjustments can be made, whether that's dropping the Oxaliplatin, decreasing the dosage, taking longer breaks, etc.

Definitely keep your oncologist updated on all side effects. Dosage levels can be reduced and could save you permanent side effects later. Most of mine side effects from oxi only lasted a couple days after an infusion. First bite, sensitive to cold, and tingling in hands and feet. Did have diarrhea also. Meds can also be prescribed to help with side effects. The neuropathy I experience now did not really kick in until after I finished treatment. Annoying, but livable. Good Luck, when do you start?
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoidoscopy/only scar tissue left
8/15 PET scan NED
9/15 LAR
0/24 nodes
10/15 blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 C 4mm lung nod
10/17 pel/abd CT NED
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, CT pel/abd/lung NED
11/18 CEA .6
5/19 CT NED, CEA <.5
10/19 Clear colonscopy
11/19 CEA <.5


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