CEA and thyroid

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dianetavegia
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CEA and thyroid

Postby dianetavegia » Mon Nov 13, 2017 11:35 am

While searching for a reason for my CEA to have risen to 5.8, I found an article about hypothyroid and false elevations in CEA. I asked my onc for thyroid testing and the results came back that I do have an under active thyroid. I can't get in to see a doctor for over a month so have asked my oncologist to start me on the med. The papers said it takes 4 to 9 months for the CEA to return to your norm AFTER your thyroid is under control.

I have a lung CT and MRI of abdomen and pelvis on 11/21 with results the next day. PRAYING it's just my thyroid causing this rise and not anything else.

If you have an elevated CEA and no cancer is found, ask for a thyroid check. Also, there are a number of papers on this so push your doctor. Mine had no idea but I had taken the article to him.

Elevated concentration of serum carcinoembryonic antigen in hypothyroidism

In this case-report we describe two patients with hypothyroidism and increased carcinoembryonic antigen (CEA) serum concentration. CEA serum concentrations reverted almost completely to the normal range values after the patients were given the hormonal replacement therapy with L-thyroxine. Although the association of hypothyroidism with elevated CEA serum concentrations has been already reported in the literature, hypothyroidism is usually disregarded when a physician is facing with a patient with increased CEA levels. On the contrary, our data suggest that hypothyroidism should be taken into account in the diagnostic work-up of these patients, such as smoking, cholestasis, impaired liver function, chronic inflammatory bronchial and bowel disease.
Stage IIIB cc surgery 1/7/09. 5/17 nodes. 12 tx FOLFOX
Stage IVa 2/15/12. CEA 6.4 PET = 1.5cm liver met. HR 4/11/12 No chemo

Eight yrs, 10 months since original dx. Five yrs. 7 months post liver resection.
“O Lord my God, I cried out to You, And You healed me.”
Psalms 30:2

Detox
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Joined: Fri Apr 28, 2017 5:27 pm

Re: CEA and thyroid

Postby Detox » Mon Nov 13, 2017 4:41 pm

Happy to hear that your getting your scans next week, just for the sake of peace of mind.

I'm still optimistic you'll be fine as the circumstantial evidence is in your favor after being NED for so long.

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dianetavegia
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Facebook Username: Diane Weldy Tavegia
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Re: CEA and thyroid

Postby dianetavegia » Tue Nov 14, 2017 7:41 pm

Yeah, Detox. My onc had said six months ago that to be 8 plus years out with only one met 5 years ago would put me at about a 1 % chance of having a recurrence. He also felt that because of my age, I'd not live long enough to develop cancer from my umpteen dozen CT's, MRI's, PET scans.

I can't get in with a regular doctor until mid December and my onc ignored my phone call/ email asking if he'd start me on a low dose thyroid med so we can see if that brings my CEA down.

Scans are a week from today. I'm not anxious this time! It might start later, but this is a first for me.

Jan. 7th 2018 will be 9 years since my original surgery. April 11, 2018 will be six years since my oligo/ metrochronus solitary met was removed along with 80% of my liver and no follow up chemo. I would LOVE to make it that far and be pronounced cured.
Stage IIIB cc surgery 1/7/09. 5/17 nodes. 12 tx FOLFOX
Stage IVa 2/15/12. CEA 6.4 PET = 1.5cm liver met. HR 4/11/12 No chemo

Eight yrs, 10 months since original dx. Five yrs. 7 months post liver resection.
“O Lord my God, I cried out to You, And You healed me.”
Psalms 30:2

lpas
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Joined: Wed Nov 19, 2014 11:11 pm

Re: CEA and thyroid

Postby lpas » Tue Nov 14, 2017 11:10 pm

Thinking of you, Diane. Keeping fingers, toes and everything else crossed that this turns out to be nothing!
11/14: Dx sigmoid CC @ 45yo
12/14: laparoscopic colectomy, hysterectomy
T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15: XELOX, celecoxib & many supplements
3/16: Ovarian mass removed. Benign fibroid
9/16: clean colonoscopy
3/17: clean CT
Ongoing: celecoxib, cimetidine & other carefully-targeted supplements
Post-chemo CEA: 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6
Mom to a 3 & 6yo

weisssoccermom
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Joined: Thu May 10, 2007 2:32 pm
Location: Pacific NW

Re: CEA and thyroid

Postby weisssoccermom » Wed Nov 15, 2017 12:57 am

Diane...I can understand why your onc won't start you on a thyroid medication. Just because your blood levels are low, most docs want to know WHY your thyroid is low. Do you Hashimoto's or something else? When I was dxd with Hashimoto's, it was after many blood tests and a nuclear scan of my thyroid. The endocrinologist wanted to know just exactly what he was dealing with. There are many reasons for an underactive thyroid....the most common being an automimmune problem like Hashimoto's but certain medications can cause an underactive thyroid, as can a temporary inflammation of the thyroid. You may or may not have a goiter....not all are noticeable.

Just like we don't want a surgeon to Rx chemo, I personally wouldn't want an oncologist prescribing thyroid medication. After years of seeing an endocrinologist for my condition (I have been diagnosed for well over 30 years), my GP regulates my dosage. You don't just Rx a low dose....thyroid medication needs to be tweaked to each individual. Metabolism, weight, condition, etc. all have to be taken into consideration. In addition, the brand names and the generics (for example, Synthroid (brand) and levoxyl (generic)) may have the same formulation but can react differently with the same person. Every year, I have my levels tested and almost always, my dosage is changed. Losing/gaining weight can have an impact on your medication dosage. I've become very astute at knowing if and when my thyroid medication needs adjusting.....sometimes it is just the most minutest of change....but it's evident to me. My meds had to be adjusted while I was on chemo....not sure why but the chemo had its effect on everything....including my thyroid.

I know its hard but please wait until the doctor who has more experience with the thyroid can see you and possibly run more tests to determine exactly what you are dealing with.
Good luck with your scans. It isn't too much longer until they are done.
Dx 6/22/2006 IIA rectal cancer
6 wks rad/Xeloda -finished 9/06
1st attempt transanal excision 11/06
11/17/06 XELOX 1 cycle
5 months Xeloda only Dec '06 - April '07
10+ blood clots, 1 DVT 1/07
transanal excision 4/20/07 path-NO CANCER CELLS!
NED now and forever!
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MissMolly
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Location: Portland, Ore

Re: CEA and thyroid

Postby MissMolly » Wed Nov 15, 2017 8:56 am

Diane:
I echo Weissoccermom’s advice and comments.

While I can appreciate your over-riding focus on your CEA value and wanting to see the CEA score lower to normal range, adding thyroid replacement is a more delicate and complex science than calling your oncologist to prescribe a low dose of thyroid medication.

There are two different manifestations of low thyroid function: a. Central (pituitary gland based); and b. Secondary or Hashimoto’s (auto-immune thyroid based).

I have central hypothyroidism (thyroid failure due to pituitary failure). Treatment for central hypothyroidism is different than for secondary hypothyroidism. Why your thyroid is underperforming is important to diagnosis in order to know which thyroid replacement options are appropriate for you.

There are several different thyroid replacement medications, each with a different mechanism of action and effect on free T3 and free T4 serum levels. Because the thyroid communicates with other endocrine glands based on serum blood levels and feedback loops, it is important to have a knowledgeable endocrinologist make an assessment. There are downstream effects as one begins to treat a low performing thyroid gland.

Do not rush into instigating a thyroid replacement medication. The endocrine system plays a vital role across in the physiology of ALL of the body’s organs and body systems. Take the time necessary to consult with an endocrinologist.
Karen
Devoted daughter to my father, diagnosed with stage 2 colon cancer Nov-2014.
Dear friend to Bella Piazza, former CC member.
I have a permanent ileostomy and offer advice on living with an ostomy.
I have been on Palliative Care for broad endocrine failure + Addison's disease + osteonecrosis of both hips/jaw + immunosuppression and recurrent infection x 4 years. I transitioned to Hospice Sept-2016, but it was not yet my time. I am back on Palliative Care and live a simple life due to frail health.

lpas
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Joined: Wed Nov 19, 2014 11:11 pm

Re: CEA and thyroid

Postby lpas » Wed Nov 22, 2017 11:04 am

dianetavegia wrote:While searching for a reason for my CEA to have risen to 5.8, I found an article about hypothyroid and false elevations in CEA. I asked my onc for thyroid testing and the results came back that I do have an under active thyroid. I can't get in to see a doctor for over a month so have asked my oncologist to start me on the med. The papers said it takes 4 to 9 months for the CEA to return to your norm AFTER your thyroid is under control.

I have a lung CT and MRI of abdomen and pelvis on 11/21 with results the next day. PRAYING it's just my thyroid causing this rise and not anything else.

If you have an elevated CEA and no cancer is found, ask for a thyroid check. Also, there are a number of papers on this so push your doctor. Mine had no idea but I had taken the article to him.


Best of luck today, Diane--you are in my thoughts. Please let us know how it goes.
11/14: Dx sigmoid CC @ 45yo
12/14: laparoscopic colectomy, hysterectomy
T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15: XELOX, celecoxib & many supplements
3/16: Ovarian mass removed. Benign fibroid
9/16: clean colonoscopy
3/17: clean CT
Ongoing: celecoxib, cimetidine & other carefully-targeted supplements
Post-chemo CEA: 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6
Mom to a 3 & 6yo

Detox
Posts: 7
Joined: Fri Apr 28, 2017 5:27 pm

Re: CEA and thyroid

Postby Detox » Wed Nov 22, 2017 11:46 am

Hope your scans are all clear and you can breathe a sigh of relief.


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