IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

Postby Maia » Tue Oct 17, 2017 2:01 pm

IMMUNO CLINICAL TRIAL FOR RECTAL CANCER, **before surgery**, at MD Anderson:
the possibility of receive an IMMUNOTHERAPY just at the start of treatment.

Talimogene Laherparepvec [T-VEC, Imlygic, immunotherapy approved for melanoma, given as injection to the tumour ]Capecitabine, and Chemoradiation Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer NCT03300544
Rectal Adenocarcinoma
Stage III Rectal Cancer AJCC v7
Stage IIIA Rectal Cancer AJCC v7
Stage IIIB Rectal Cancer AJCC v7
Stage IIIC Rectal Cancer AJCC v7
Stage IV Rectal Cancer AJCC v7
Stage IVA Rectal Cancer AJCC v7
Stage IVB Rectal Cancer AJCC v7

https://clinicaltrials.gov/ct2/show/NCT03300544

NHMike
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Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

Postby NHMike » Tue Oct 17, 2017 2:06 pm

Too late for me but it sounds cool. Basically hitting the tumor with a triple-attack.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

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CRguy
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Re: IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

Postby CRguy » Tue Oct 17, 2017 4:26 pm

Just an IMO moment here Maia ...

I think this absolutely legitimizes and brings immunotherapies into the forefront of mainline CRC protocols,
as a first line therapy for ALL Stage III and IV classes = this is GREAT news !
Hoping for great results !

JMO

Cheers
CR
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

mozart13
Posts: 140
Joined: Fri Dec 09, 2016 7:38 pm
Location: Toronto

Re: IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

Postby mozart13 » Wed Oct 18, 2017 12:20 pm

It looks like the cause of most cancers are Immuno failing of the body to reckognize and fight.
“And yet it moves” like Galileo said, we are going in right direction.

Thx Maia for updates!
55 year at the time of diagnosis, male
Diagnosed with T1,T2 N0 M0 rectal cancer
Total neoadjuvant therapy or TNT (chemoradiation followed by systemic chemotherapy)
Negative since Feb. '17
No surgery
Watch&Wait approach 8)
I don’t come much to forum , so if this is not updated it means I remain negative!
Wish good luck to all!

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Re: IMMUNO-combo trial RECTAL CANCER *before* surgery -at MD Anderson

Postby Maia » Wed Oct 18, 2017 1:23 pm

mozart13 wrote:It looks like the cause of most cancers are Immuno failing of the body to reckognize and fight.

Absolutely. So we can keep cutting, poisoning, radiating, taking out the cancer (we need to do that!) but if the (immune) system who failed to stop the misguided cells, in the first place, is not addressed, it's unlikely we'll be able to talk about a cure.


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