Durvalumab and Cediranib Clinical trial - I'm in!

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KElizabeth
Posts: 390
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Wed Oct 11, 2017 2:00 pm

I've just started on the following trial:
https://clinicaltrials.gov/ct2/show/NCT02484404

I've done 4 weeks of Cediranib and have had one dose of Durvalumab and feel mostly normal so far. It's still to early to say because I'm still recovering from 22 months of Folfiri.
Fingers and toes crossed!
Female age 38- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 -current
CEA at recurrence:10.1/august, 2015
CEA: 1.9 February, 2016
CEA: 16.4 March 2017
CEA: 90.1 October 2017

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peanut_8
Posts: 2168
Joined: Sun May 25, 2014 1:31 pm
Location: Capital of Texas

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby peanut_8 » Wed Oct 11, 2017 8:54 pm

Good luck KElizabeth.

Crossing both fingers and toes.
peanut
Terri aka peanut
diagnosed Jan 14, RC stage 2a, age 56
permanent colostomy
MSS
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED

sdino
Posts: 43
Joined: Tue Mar 28, 2017 5:32 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby sdino » Fri Oct 13, 2017 6:40 am

Wishing you much success !
Caregiver for Wife 52 yrs old
DX:11/16-CC sigmoid colon 3 cm, Lung Adenocarcinoma Stg IV
Mets: 1.2 cm now 7 mm lung w/14 other nodules less than 6 mm. 7/17 growth in Mets
MSS, KRAS-mut G12D; TP53;
Completed 12 rounds Folfox/Avastin + Oxi 11/16 to 5/17
8/17 Start Xeloda + Avastin
CT Scans: 11/16; 1/17 lung mets/colon shrinkage; 5/17 colon & lung met shrinkage, 7/17 and 11/17 disease progression lungs/colon
CEA: 16 - 11/16; 4 – 12/16; 0.5 – 2/17; 0.6 - 5/17; 2.6 - 7/17; 10/17 - 1.9, 11/17 - 2.6

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Maia » Fri Oct 13, 2017 8:09 am

Everything crossed!! A great combo!!

boswind
Posts: 32
Joined: Fri Apr 11, 2014 12:04 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby boswind » Sun Nov 19, 2017 8:41 am

KElizabeth,

Have you had a CT SCAN since you started the clinical trial?

I am looking for clinical trials. It is worthwhile to get more info abou this one.

Thanks,
01.24.2014 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.2014 Completed 5-week Radia+Xeloda
05.07.2014 Had surgery to remove 13cm sigmoid-colon and rectum.
02.25.2015 PET/CT/MRI scans show liver mets and L4 Spine involvement.
MSS, KRAS wild type, BRAF wild type
Mar 2015 - Aug 2015, folfox + Avastin
Aug 2015 - Jul 2017, 5FU + leucovorin + Avastin for Maintainance
Jul 2017 - Present, folfuri + Avastin
Current CEA: 5.6
Total over 50 rounds of chemo treatment received

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susie0915
Posts: 549
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby susie0915 » Sun Nov 19, 2017 9:09 am

Good Luck. Keep us updated.
58 yr old mother of 3 Dx @ 55
5/15 DX T3N0MO/ 2A
6/15 5 wks of chemo/rad
7/15 sigmoidoscopy/scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. 3 1/2 weeks in hospital,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod onc thinks scar tissue
monitored for autoimmune disorder/interstitial lung disease
7/17 no change lung nodule
10/17 Clear CT
11/17 CEA<.5

KElizabeth
Posts: 390
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Wed Nov 22, 2017 9:12 am

boswind wrote:KElizabeth,

Have you had a CT SCAN since you started the clinical trial?

I am looking for clinical trials. It is worthwhile to get more info abou this one.

Thanks,

I scan next werk for the first time. I'll post here whenI get results.
Female age 38- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 -current
CEA at recurrence:10.1/august, 2015
CEA: 1.9 February, 2016
CEA: 16.4 March 2017
CEA: 90.1 October 2017

NHMike
Posts: 683
Joined: Fri Jul 21, 2017 3:43 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby NHMike » Wed Nov 22, 2017 9:30 am

Best wishes on your clinical trial.
6/23/17: ER rectal bleeding; Colonoscopy+Biopsy
7/13: Stage 3B rectal cancer. T3, N1b, M0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6 mm, 5 x 5 mm
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8. 11/30: 0.6
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 mm (-75%), 5 x 3 mm (-40%). 5.1 CM from AV
10/30: Surgery: LAR, Temp Ileostomy
Path report: Tumor regression grade: 0 (complete response).

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Robino1
Posts: 221
Joined: Fri Aug 11, 2017 12:09 pm
Facebook Username: Robin.lawthers
Location: Florida

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Robino1 » Wed Nov 22, 2017 9:44 am

Fingers and toes crossed!!!
At 54 2014 1st colonoscopy colon cancer detected.
Colon resect right ascending
margins clear. No chemo Stage II
2017
Distended abd, pain in intestines.
CT scan shows seeding
Ascites
Lap diag - cancer on the omentum
CEA 217
CEA 219
PET cancer on the omentum, susp activ right abdomen
FOLFOX started 6/17
CEA 202
Not genetic
8/29/17 CT scan showed excellent melting of the tumor. Chemo is working!
Ascites is gone
CEA: 9/30/17 -109; 10/12/17 - 99.1; 11/4/17 - 90.7; 11/30/17 - 70.7
BRAF V600e mutation :(

Zig2017
Posts: 59
Joined: Tue Sep 26, 2017 12:26 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Zig2017 » Thu Nov 23, 2017 5:51 pm

All the best on your clinical trial!!
Hubby stage 3C June 2017
MSS BRAF Mutation
18 LN positive
Adenosquamous CC
12 FOLFOX
Right Hemicolectomy
11/08/17 numerous nodules and lymph nodes throughout chest and abdomen. Stage IV.
11/2017 moved care to Sloan clinical trial for BRAF mutation

KElizabeth
Posts: 390
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Thu Nov 30, 2017 11:33 pm

Scan results are in and I've had significat disease progression. I'm out of the trial.
Time for plan B.
The doctors at NIH think Hard chemo is needed for awhile. We're considering some trials and maybe we'll start with a few desensitization treatments of Oxaliplatin while we look for other options.
Female age 38- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 -current
CEA at recurrence:10.1/august, 2015
CEA: 1.9 February, 2016
CEA: 16.4 March 2017
CEA: 90.1 October 2017

NHMike
Posts: 683
Joined: Fri Jul 21, 2017 3:43 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby NHMike » Fri Dec 01, 2017 9:47 am

Do you know your KRAS mutation?
6/23/17: ER rectal bleeding; Colonoscopy+Biopsy
7/13: Stage 3B rectal cancer. T3, N1b, M0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6 mm, 5 x 5 mm
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8. 11/30: 0.6
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 mm (-75%), 5 x 3 mm (-40%). 5.1 CM from AV
10/30: Surgery: LAR, Temp Ileostomy
Path report: Tumor regression grade: 0 (complete response).

KElizabeth
Posts: 390
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Mon Dec 04, 2017 11:21 am

NHMike wrote:Do you know your KRAS mutation?

Yes. I have KRAS mutation as well as TP53 and APC.
Female age 38- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 -current
CEA at recurrence:10.1/august, 2015
CEA: 1.9 February, 2016
CEA: 16.4 March 2017
CEA: 90.1 October 2017

jortego128
Posts: 275
Joined: Sat Aug 15, 2015 7:47 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby jortego128 » Tue Dec 05, 2017 6:56 am

KElizabeth wrote:Scan results are in and I've had significat disease progression. I'm out of the trial.
Time for plan B.
The doctors at NIH think Hard chemo is needed for awhile. We're considering some trials and maybe we'll start with a few desensitization treatments of Oxaliplatin while we look for other options.



Sorry to hear this, hopefully they can find another good trial for you ASAP!
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

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peanut_8
Posts: 2168
Joined: Sun May 25, 2014 1:31 pm
Location: Capital of Texas

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby peanut_8 » Tue Dec 05, 2017 10:37 am

That really sucks. Stupid cancer.

Best Wishes for a productive Plan B.
penut
Terri aka peanut
diagnosed Jan 14, RC stage 2a, age 56
permanent colostomy
MSS
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED


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