Durvalumab and Cediranib Clinical trial - I'm in!

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KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Wed Oct 11, 2017 2:00 pm

I've just started on the following trial:
https://clinicaltrials.gov/ct2/show/NCT02484404

I've done 4 weeks of Cediranib and have had one dose of Durvalumab and feel mostly normal so far. It's still to early to say because I'm still recovering from 22 months of Folfiri.
Fingers and toes crossed!
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

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peanut_8
Posts: 2222
Joined: Sun May 25, 2014 1:31 pm
Location: Capital of Texas

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby peanut_8 » Wed Oct 11, 2017 8:54 pm

Good luck KElizabeth.

Crossing both fingers and toes.
peanut
Terri aka peanut
diagnosed Jan 14, RC stage 2a, age 56
permanent colostomy
MSS
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED

sdino
Posts: 56
Joined: Tue Mar 28, 2017 5:32 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby sdino » Fri Oct 13, 2017 6:40 am

Wishing you much success !
Caregiver for Wife 52 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-1.5cm
MSS, KRAS-mut G12D; TP53
Completed 12 rounds Folfox/Avastin + Oxi 11/16 to 5/17, 8/17 Start Xeloda + Avastin
CT Scans: 5/17 colon & lung met shrinkage,11/17 and 1/18 slight progression lungs/colon; 5/18 stable lungs/colon
NCI YOUNGER TIL Trial NCT03412877 - 1/18 VATs lung surgery 2 mets wedge resect
CEA: 16 - 11/16; 0.6 - 5/17; 3.0 - 11/17; 4.4 - 1/18; 5.7 - 2/18; 4.9 - 3/18, 4.0 - 5/18

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Maia » Fri Oct 13, 2017 8:09 am

Everything crossed!! A great combo!!

boswind
Posts: 38
Joined: Fri Apr 11, 2014 12:04 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby boswind » Sun Nov 19, 2017 8:41 am

KElizabeth,

Have you had a CT SCAN since you started the clinical trial?

I am looking for clinical trials. It is worthwhile to get more info abou this one.

Thanks,
01.24.2014 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.2014 Completed 5-week Radia+Xeloda
05.07.2014 Had surgery
02.25.2015 CT showed liver and L4 Spine involvement.
03.2015 - 08.2015, folfox + Avastin
08.2015 - 07.2017, 5FU + leucovorin + Avastin for Maintenance
07.2017 - 01.2018, Folfuri + Avastin
01.25.2018 - present, Centuximab + Irinotecan
70 rounds of chemos received (as of 03.2018)
Current CEA: 5.7
MSS, KRAS wild type, BRAF wild type

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susie0915
Posts: 775
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby susie0915 » Sun Nov 19, 2017 9:09 am

Good Luck. Keep us updated.
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoid/scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod
7/17 no change lung nod
10/17 Clear pel/abd CT
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, clear CT pel/abd/lung nod no change

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Wed Nov 22, 2017 9:12 am

boswind wrote:KElizabeth,

Have you had a CT SCAN since you started the clinical trial?

I am looking for clinical trials. It is worthwhile to get more info abou this one.

Thanks,

I scan next werk for the first time. I'll post here whenI get results.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

NHMike
Posts: 1362
Joined: Fri Jul 21, 2017 3:43 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby NHMike » Wed Nov 22, 2017 9:30 am

Best wishes on your clinical trial.
6/23/17: ER rectal bleeding; Colonoscopy
7/13: Stage 3B rectal. T3N1bM0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/30: LAR, Temp Ileostomy, Path Complete Response
12/20: Started CapeOx

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Robino1
Posts: 452
Joined: Fri Aug 11, 2017 12:09 pm
Facebook Username: Robin.lawthers
Location: Florida

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Robino1 » Wed Nov 22, 2017 9:44 am

Fingers and toes crossed!!!
At 54 2014 1st colonoscopy colon cancer detect
Colon resect margins clear. No chemo Stage II
2017
Distend abd, pain in intestines.
CT scan seeding & Ascites
Lap diag - cancer on the omentum
CEA 217; 219
FOLFOX started 6/17
CEA 202
8/29/17 CT melting of tumor.
Latest CT scan shows 2 new tumors and return of ascites.
CEA: (2017)9/30 -109; 10/12 -99.1; 11/4 -90.7; 11/30 -70.7; 12/14 -83.4; (2018)1/4 -73.3; 2/1-84.2; 89.2; 89.8; 88.5; 81.8: 93.5; 107; 119
BRAF V600e

Zig2017
Posts: 139
Joined: Tue Sep 26, 2017 12:26 pm

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby Zig2017 » Thu Nov 23, 2017 5:51 pm

All the best on your clinical trial!!
Hubby stage 3C June 2017
MSS BRAF Mutation
18 LN positive
Adenosquamous CC
12 FOLFOX
Right Hemicolectomy
11/08/17 numerous nodules and lymph nodes throughout chest and abdomen. Stage IV.
11/2017 moved care to Sloan clinical trial for BRAF mutation
1/30/18 off clinical trial
2/2/18 one dose of Irinotecan
2/5/18 Hospitalization and hospice
2/16/18 came home from hospital and went home to his Lord at 1:10 pm

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Thu Nov 30, 2017 11:33 pm

Scan results are in and I've had significat disease progression. I'm out of the trial.
Time for plan B.
The doctors at NIH think Hard chemo is needed for awhile. We're considering some trials and maybe we'll start with a few desensitization treatments of Oxaliplatin while we look for other options.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

NHMike
Posts: 1362
Joined: Fri Jul 21, 2017 3:43 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby NHMike » Fri Dec 01, 2017 9:47 am

Do you know your KRAS mutation?
6/23/17: ER rectal bleeding; Colonoscopy
7/13: Stage 3B rectal. T3N1bM0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/30: LAR, Temp Ileostomy, Path Complete Response
12/20: Started CapeOx

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby KElizabeth » Mon Dec 04, 2017 11:21 am

NHMike wrote:Do you know your KRAS mutation?

Yes. I have KRAS mutation as well as TP53 and APC.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

jortego128
Posts: 279
Joined: Sat Aug 15, 2015 7:47 am

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby jortego128 » Tue Dec 05, 2017 6:56 am

KElizabeth wrote:Scan results are in and I've had significat disease progression. I'm out of the trial.
Time for plan B.
The doctors at NIH think Hard chemo is needed for awhile. We're considering some trials and maybe we'll start with a few desensitization treatments of Oxaliplatin while we look for other options.



Sorry to hear this, hopefully they can find another good trial for you ASAP!
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

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peanut_8
Posts: 2222
Joined: Sun May 25, 2014 1:31 pm
Location: Capital of Texas

Re: Durvalumab and Cediranib Clinical trial - I'm in!

Postby peanut_8 » Tue Dec 05, 2017 10:37 am

That really sucks. Stupid cancer.

Best Wishes for a productive Plan B.
penut
Terri aka peanut
diagnosed Jan 14, RC stage 2a, age 56
permanent colostomy
MSS
April 14, 28 chemo/rad with Xeloda
June 14 adjuvant Xeloda 6 rounds
currently NED


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