Sara!!!! wrote:Hey everyone. My mom is a stage 4 colon patient. With mets to liver and now a possible omental involvement. I wanted to ask about someones experience with cimetidine? Has anyone taken it? Did it help?
mpbser wrote:While we can't be certain, my husband and I credit cimetidine (plus graviola, other supplements, better diet and exercise) with absence of any new tumors since he was originally diagnosed.
mpbser wrote:He started taking cimetidine about a month or so before his colon surgery, 800 mg a day, with only a week off prior to surgery and then resumed about a week afterwards. He still takes it so it has been about 6 months now. He starts chemo in a couple of weeks and I'm not sure what he is going to do then. There are threads on this forum about that and I'm going to review them again soon.
lpas wrote:I've been taking 800mg daily since shortly after my diagnosis in 2014 and I do believe strongly that it helps--particularly in the immediate pre- and post-surgical periods.
JJH wrote:Cimetidine for Cancer Treatment
http://www.lifeextension.com/magazine/2002/7/cover_cimetidine/Page-01
rp1954 wrote:I would encourage you to get, and discuss the extra bloodwork done to productively compare experiences and improve results.
My wife used 1600 mg/day of cimetidine, along with a number of supplements before and after two surgeries; cimetidine explicitly during the second surgery for her para aortic lymph nodes. She has had IV vitamin C up to within 10-12 hours following surgery, closer than most. (The closest I've heard of, is for "instant recovery" from anesthesia following surgery) She also used baby aspirin but discontinued it up to 7 days before GI surgery. These are reputed in various circles, outside standard practice, to have various immune modulating, anti-inflammatory, anticancer, wound healing properties. Basically we worked hard to select the biggest, baddest kitchen sink and aim "excessive supplements" at the cancer before and after surgery as we could safely arrange for her. Some things we used more than LEF and others less, partly limited by time, availability and intake (pill) burden.
Before her first surgery, my wife appears to have had a localized complete immune response to her peritoneal involvement and fat infiltrations, with a massive granulocyte attack and dead masses, among other successes. Like most advanced CRC patients she had massive amounts of neutrophils, the major type of granulocyte, circulating. Apparently, we recruited them, where lymphocyte and granulocyte attacks are mentioned in various cimetidine lab papers. This along with all the other stuff, various heavy duty supplements for up to 4 weeks.
Surgeons are going to be conservative about supplements and pretreatments; their knowledge base and approaches can vary greatly. Most were leary in 2010-11; some may be helpful and there has been some recognition of therapeutic perioperative nutrition since then. Our experience base for two surgeries and the papers used were not about liver surgeries. Length of surgery, interaction and bleeding are bigger concerns with liver surgery.
The papers that actively concern cimetidine for surgery are mostly from the 80s and early 90s, ancient texts to some medical biases, from when it was the prime treatment for the prophylaxis of acid aspiration in surgery. It was from this base (thanks to Life Extension Foundation articles) that we requested cimetidine for the 2nd surgery, where surgeons have their own surgical tables, cheat sheets and summaries. IV cimetidine is much harder to get these days (China or compounding pharmacy with a long lead time?), so our surgeons allowed oral use for surgery, despite npo, which we happened to have a box of 400 mg tabs.
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