Keytruda? What else is new?

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angielada
Posts: 9
Joined: Wed May 13, 2015 5:14 am

Keytruda? What else is new?

Postby angielada » Mon Sep 25, 2017 12:10 am

It's been awhile since I've been on... what's up with Keytruda? Anything else i should know about?
Quick overview:
Hubby originally stage 3.. then became stage 4 with liver mets and others showing in abdomen and around that area.
6 months of Folfiri with Avastin shrunk EVERYTHING (we also did Iscador injections we got from Germany along with NO CARB OR SUGAR diet by Dr Barker in Pasadena)
The treatment was so successful he was eligible for liver resection after few months. When the surgeon did the surgery couldn't see all the spots they were too small.
Free months later radioablation for leftover spots in liver.. then few months later more spots and another ablation..now more spots and ablation was canceled.
He will go back to Folfiri/Avastin this week...but what is up with Keytruda?
He has 4 small spots confined to liver.
Any suggestions?
Thanks thanks thanks!
Wife of stage iv cc
11-20-14: stage iii colon resection
12-20-14: started chemo oxiliplatin xeloda every 3 weeks about 6.5 months i think
9-1-15: ct clear
2-8-16: upgraded to stage iv liver and abdominal mets very aggressive kras mutation positive
2-12-16: start chemo folfiri with avastin
7-28-16: Liver resection
2-10-17: spots back in liver
4-17-17 : radioablation is scheduled
May 17; radioablation
July 17: radioablation
Sept '17: radioablation canceled bc of new spots. Chemo scheduled

veckon
Posts: 94
Joined: Thu Jul 27, 2017 7:44 am

Re: Keytruda? What else is new?

Postby veckon » Mon Sep 25, 2017 8:56 am

angielada wrote:It's been awhile since I've been on... what's up with Keytruda? Anything else i should know about?
Quick overview:
Hubby originally stage 3.. then became stage 4 with liver mets and others showing in abdomen and around that area.
6 months of Folfiri with Avastin shrunk EVERYTHING (we also did Iscador injections we got from Germany along with NO CARB OR SUGAR diet by Dr Barker in Pasadena)
The treatment was so successful he was eligible for liver resection after few months. When the surgeon did the surgery couldn't see all the spots they were too small.
Free months later radioablation for leftover spots in liver.. then few months later more spots and another ablation..now more spots and ablation was canceled.
He will go back to Folfiri/Avastin this week...but what is up with Keytruda?
He has 4 small spots confined to liver.
Any suggestions?
Thanks thanks thanks!


If his tumors are MSI-H, it could be an effective treatment. Working well for me so far, though side effects are beginning to catch up with me.
27 yo male
Metastatic rectal cancer diagnosed 12/16
Liver metastases and peritoneal carcinomatosis
Lynch syndrome, MSI-H
Failed liver resection 3/17
FOLFOX6 12/16 - 05/17
Keytruda 5/17 - present
@Memorial Sloan Kettering

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: Keytruda? What else is new?

Postby BIG ROB 69 » Thu Sep 28, 2017 10:46 am

Veckon, what side effects, and since when?
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

veckon
Posts: 94
Joined: Thu Jul 27, 2017 7:44 am

Re: Keytruda? What else is new?

Postby veckon » Thu Sep 28, 2017 11:08 am

Fatigue is the most persistent. It started out as just standard fatigue, but has since progressed to what can only be described as narcoleptic. The last two weeks I have seen a large increase in bleeding during loose bowel movements, which have become frequent enough to keep me from sleeping. I was hospitalized for slight anemia a few days ago because of this, but other than that my blood work actually looks good. I am at Sloan Kettering now actually waiting to be examined by my colorectal surgeon in greater detail.
27 yo male
Metastatic rectal cancer diagnosed 12/16
Liver metastases and peritoneal carcinomatosis
Lynch syndrome, MSI-H
Failed liver resection 3/17
FOLFOX6 12/16 - 05/17
Keytruda 5/17 - present
@Memorial Sloan Kettering

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: Keytruda? What else is new?

Postby BIG ROB 69 » Thu Sep 28, 2017 1:13 pm

I've also slept the days away, and have been dealing with mouth sores,chapped lips and a sore throat. Up intil recent with the steroids and anti-fungals have I felt aome relief. Good luck to ya bro.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

henry123
Posts: 10
Joined: Sun Oct 08, 2017 3:25 am

Re: Keytruda? What else is new?

Postby henry123 » Tue Oct 10, 2017 11:47 am

veckon wrote:Fatigue is the most persistent. It started out as just standard fatigue, but has since progressed to what can only be described as narcoleptic. The last two weeks I have seen a large increase in bleeding during loose bowel movements, which have become frequent enough to keep me from sleeping. I was hospitalized for slight anemia a few days ago because of this, but other than that my blood work actually looks good. I am at Sloan Kettering now actually waiting to be examined by my colorectal surgeon in greater detail.


Please consider an hour of yoga daily.
It will build up your strength and stamina especially with deep breathing exercises.
Also my haemoglobin levels improved substantially with fresh pomegranate, carrots and beets juice.
I am currently on opdivo with liver, lung and peritoneal mets. Cea levels coming drastically with opdivo.

User avatar
Maia
Posts: 2436
Joined: Fri Aug 24, 2012 8:00 am

Re: Keytruda? What else is new?

Postby Maia » Fri Oct 13, 2017 9:09 am

Pembrolizumab (Keytruda) and nivolumab (Opdivo) are a type of immunotherapy, both approved some months ago, as monotherapy, for those with CRC whose MS status is MSI-high (about a 10% of the CRC are MSI high). For the majority of the CRC patients, who are MSS, those agents and similar are being tested in combinations --that is: immunotherapy + [something else]. You have a link to a clinical trial finder in my signature line; the finder is curated by Tom Marsilje --DK37 in this forum.

And there are many ablation options and other treatments for the liver. It depends of where you are located, if you can travel, etc.


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